Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Developmental expression and modification of genes.

N Benvenisty1, L Reshef

  • 1Department of Developmental Biochemistry, Hebrew University-Hadassah Medical School, Jerusalem, Israel.

Biology of the Neonate
|January 1, 1987
PubMed
Summary

Gene structure modifications, including chromatin and DNA methylation changes, regulate developmental protein expression in vertebrates. Hormones may influence these epigenetic modifications, impacting gene activity during development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Increasing adherence to the Mediterranean diet and lifestyle is associated with reduced fecal calprotectin and intra-individual changes in microbial composition of healthy subjects.

Gut microbes·2022
Same author

Adherence to the Mediterranean diet is associated with decreased fecal calprotectin in patients with ulcerative colitis after pouch surgery.

European journal of nutrition·2019
Same author

An electrode-assisted anaerobic digestion process for the production of high-quality biogas.

Water science and technology : a journal of the International Association on Water Pollution Research·2019
Same author

Fruit Consumption is Associated with Alterations in Microbial Composition and Lower Rates of Pouchitis.

Journal of Crohn's & colitis·2019
Same author

Microbiome associated with denture malodour.

Journal of breath research·2018
Same author

Factors involved in self-renewal and pluripotency of embryonic stem cells.

Handbook of experimental pharmacology·2005

Area of Science:

  • Developmental Biology
  • Epigenetics
  • Molecular Biology

Background:

  • Differentiating tissues exhibit unique protein profiles, with some proteins being developmentally regulated.
  • Understanding the genetic control of these developmentally regulated proteins is crucial for developmental biology.

Purpose of the Study:

  • To review modifications in gene structure encoding developmentally regulated proteins.
  • To discuss the role of epigenetic changes like DNA methylation and chromatin conformation in gene regulation.
  • To explore the influence of hormones on DNA modifications and their interrelationship with gene expression.

Main Methods:

  • Review of existing literature on gene structure modifications.
  • Analysis of evidence for changes in chromatin conformation and DNA methylation in vertebrates.
  • Discussion of hormonal regulation and gene expression interrelationships.

Main Results:

  • Evidence presented for changes in chromatin conformation and DNA methylation of specific genes during vertebrate development.
  • Hormonal involvement in regulating DNA modifications is suggested.
  • Interrelationships between DNA modifications and gene expression are discussed.

Conclusions:

  • Epigenetic modifications, including DNA methylation and chromatin changes, are key mechanisms controlling developmentally regulated gene expression.
  • Hormones likely play a role in mediating these epigenetic alterations.
  • These modifications are fundamental to understanding vertebrate development.

Related Experiment Videos