Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

557
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
557
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids01:24

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

604
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
604
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

6.2K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
6.2K
Combined Effects of Drugs: Antagonism01:30

Combined Effects of Drugs: Antagonism

10.8K
The combined effects of drugs can result in various interactions, of which an important type is antagonism. Antagonism is a mechanism where one drug inhibits or counteracts the effects of another drug. Antagonism can occur through various means, including receptor binding, allosteric modulation, functional interaction, chemical reactions, and pharmacokinetic processes.
The most common type is receptor antagonism, where one drug acts as an antagonist to block the effects of another drug by...
10.8K
Hallucinogens and Psychedelics01:27

Hallucinogens and Psychedelics

444
Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
444
Agonism and Antagonism: Quantification01:14

Agonism and Antagonism: Quantification

832
When drugs are administered, they can elicit either an agonist or antagonist effect on the body. Agonism occurs when a drug activates a specific receptor, triggering a biological response. On the other hand, antagonism happens when a drug binds to the same receptors but blocks their activation, thereby preventing a biological response.
To quantify these effects, researchers use a dose-response curve, which provides valuable information about the potency and efficacy of a drug. Potency refers to...
832

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Leukocyte-intrinsic ER stress responses contribute to chemotherapy-induced peripheral neuropathy.

Science translational medicine·2025
Same author

A Thematic Text Analysis of Cannabis Edibles Brand Names.

Cannabis and cannabinoid research·2025
Same author

Association of Tetrahydrocannabinol Content and Price in Herbal Cannabis Products Offered by Dispensaries in California: A Purview of Consumers/Patients.

Frontiers in public health·2022
Same author

Potency and Therapeutic THC and CBD Ratios: U.S. Cannabis Markets Overshoot.

Frontiers in pharmacology·2022
Same author

Tumor-Derived Lysophosphatidic Acid Blunts Protective Type I Interferon Responses in Ovarian Cancer.

Cancer discovery·2022
Same author

Methods and protocols for translatable rodent models of postsurgical pain.

Methods in cell biology·2022

Related Experiment Video

Updated: Dec 5, 2025

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
07:51

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

614

CBD and THC: Do They Complement Each Other Like Yin and Yang?

Sarah D Pennypacker1, E Alfonso Romero-Sandoval1

  • 1Department of Anesthesiology, Pain Mechanisms Laboratory, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

Pharmacotherapy
|October 20, 2020
PubMed
Summary

Cannabidiol (CBD) may counteract some negative effects of tetrahydrocannabinol (THC), offering therapeutic cannabis benefits without intense psychoactive experiences. Research explores CBD's protective potential against THC-induced impairment.

Keywords:
cannabidiolcannabinoidscannabisintoxicationmarijuanamedical marijuanapsychosissubjective effectstrans-δ9-tetrahydrocannabinol

More Related Videos

Ultrasonic-Assisted Extraction of Cannabidiolic Acid from Cannabis Biomass
05:46

Ultrasonic-Assisted Extraction of Cannabidiolic Acid from Cannabis Biomass

Published on: May 27, 2022

6.6K
Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library
10:17

Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library

Published on: January 14, 2020

8.1K

Related Experiment Videos

Last Updated: Dec 5, 2025

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
07:51

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

614
Ultrasonic-Assisted Extraction of Cannabidiolic Acid from Cannabis Biomass
05:46

Ultrasonic-Assisted Extraction of Cannabidiolic Acid from Cannabis Biomass

Published on: May 27, 2022

6.6K
Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library
10:17

Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library

Published on: January 14, 2020

8.1K

Area of Science:

  • Pharmacology and Toxicology
  • Neuroscience
  • Cannabis Science

Background:

  • Public access to cannabis necessitates understanding its constituents and their clinical effects.
  • Tetrahydrocannabinol (THC) is the primary psychoactive compound, while cannabidiol (CBD) shows therapeutic potential (anxiolytic, antiepileptic).
  • A popular belief suggests CBD mitigates THC's adverse effects, like anxiety and impairment.

Purpose of the Study:

  • To analyze scientific evidence regarding the protective effects of CBD against THC.
  • To critically discuss the mechanistic basis for CBD's potential protective role.
  • To explore the implications for patients seeking therapeutic cannabis use.

Main Methods:

  • Comprehensive review of existing scientific literature on cannabis constituents and their interactions.
  • Critical mechanistic discussion to interpret the evidence.
  • Analysis of patient implications based on scientific findings.

Main Results:

  • Evidence is analyzed to determine if CBD provides a beneficial or protective effect against THC.
  • The study evaluates the scientific basis for the popular opinion on CBD's mitigating properties.
  • Mechanistic insights into the interaction between CBD and THC are explored.

Conclusions:

  • The article provides a scientific assessment of CBD's role in modulating THC's effects.
  • Findings are relevant for patients considering cannabis for therapeutic purposes.
  • Understanding these interactions is crucial for optimizing cannabis-based therapies.