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Methods and protocols for translatable rodent models of postsurgical pain.
James W Morgan1, Sarah D Pennypacker1, E Alfonso Romero-Sandoval1
1Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, NC, United States.
Methods in Cell Biology
|April 3, 2022
Summary
Understanding postsurgical pain mechanisms is crucial. This study details rat and mouse models for minor (paw incision) and major (skin muscle incision and retraction) surgeries to investigate pain behaviors.
Area of Science:
- Preclinical pain research
- Surgical pain modeling in rodents
Background:
- Postsurgical pain is a significant clinical issue.
- Pain intensity correlates with surgical damage severity.
- Chronic pain development is more common after major surgeries.
Purpose of the Study:
- To detail protocols for paw incision and skin muscle incision and retraction (SMIR) models.
- To provide methods for studying postsurgical pain in rats and mice.
- To facilitate research on minor and major surgical pain mechanisms.
Main Methods:
- Detailed protocols for paw incision and SMIR models in rodents.
- Measurement of reflexive, spontaneous, and functional pain-like behaviors.
- Adaptation of surgical models to human surgery aspects.
Main Results:
- Paw incision and SMIR models effectively simulate aspects of minor and major human surgeries.
- These models allow for comprehensive measurement of pain behaviors.
- Protocols are provided for researchers of varying experience levels.
Conclusions:
- Paw incision and SMIR models are valuable tools for postsurgical pain research.
- Standardized protocols enhance the reliability of rodent postsurgical pain studies.
- Understanding these models aids in developing better pain management strategies.