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Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
Published on: March 16, 2018
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Drug-Induced Ototoxicity: A Comprehensive Review and Reference Guide
Habib G Rizk1, Joshua A Lee1, Yuan F Liu2
1Department of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Pharmacotherapy
|October 20, 2020
Summary
Many common medications can cause ototoxicity, affecting hearing and balance. This review details 194 drugs with ototoxic potential, aiding healthcare providers in informed patient management.
Area of Science:
- Pharmacology
- Toxicology
- Ototoxicology
Background:
- Increasing polypharmacy raises concerns about adverse drug effects like ototoxicity.
- Healthcare professionals may underestimate the ototoxic risks of common medications.
- Ototoxicity poses significant public health implications.
Purpose of the Study:
- To create a comprehensive and user-friendly ototoxic profile of medications.
- To assess the evidence supporting the ototoxicity of various drugs.
- To enhance healthcare providers' knowledge of drug-induced ototoxicity.
Main Methods:
- Searched Micromedex, Lexicomp, and Drug Induced Diseases for ototoxic medications.
- Conducted literature searches in PubMed and Cochrane databases.
- Graded evidence of causality (A, B, C) based on study design.
Main Results:
- Identified 194 systemically administered medications linked to ototoxicity.
- Antimicrobials, psychotropics, and antihypertensives were common culprits.
- Evidence of cochleotoxicity, vestibulotoxicity, and dizziness was documented across multiple drug classes.
Conclusions:
- Ototoxicity varies based on drug and patient factors.
- This review aims to improve clinical decision-making regarding ototoxic medications.
- Informed management by healthcare providers can mitigate ototoxicity risks.
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