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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Stem Cell Niche01:26

Stem Cell Niche

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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Related Experiment Video

Updated: Dec 5, 2025

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
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Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

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Mesenchymal stromal cells for osteonecrosis.

S Elgaz1, H Bonig2, P Bader3

  • 1Department for Children and Adolescents, Division for Stem Cell Transplantation and Immunology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.

Journal of Translational Medicine
|October 21, 2020
PubMed
Summary

Mesenchymal stromal cells (MSCs) show promise for treating osteonecrosis (ON), a debilitating bone disorder. While cell therapies are safe and feasible, results are preliminary and require further investigation due to treatment variability.

Keywords:
Cell-based therapiesMesenchymal stromal cells (MSC)Osteonecrosis

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Isolation and Enrichment of Human Adipose-derived Stromal Cells for Enhanced Osteogenesis
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Area of Science:

  • Orthopedics
  • Regenerative Medicine
  • Skeletal Disorders

Background:

  • Osteonecrosis (ON) is a debilitating skeletal disorder with various causes, including vascular damage and mechanical stress.
  • Current treatments like core decompression are often ineffective, necessitating novel therapeutic approaches.
  • Mesenchymal stromal cells (MSCs) possess osteoinductive properties, making them a potential treatment for advanced ON.

Purpose of the Study:

  • To review the existing data on MSCs for advanced ON.
  • To evaluate supportive pre-clinical data from autologous bone marrow mononuclear cells (auto BM-MNCs).
  • To assess the safety and feasibility of cell-based therapies for ON.

Main Methods:

  • Review of clinical trials involving allogeneic or autologous MSCs in advanced ON.
  • Analysis of pre-clinical studies using auto BM-MNCs, focusing on MSC content.
  • Assessment of safety and complication rates associated with cell therapy administration.

Main Results:

  • Clinical trial outcomes for MSCs and auto BM-MNCs in ON are preliminary and promising but not definitive.
  • Cell therapy application was technically feasible and safe, with low complication rates.
  • Significant heterogeneity in cell products, protocols, and techniques may contribute to inconsistent results.

Conclusions:

  • MSCs represent a promising therapeutic avenue for advanced osteonecrosis.
  • Further research is needed to optimize cell therapy protocols and overcome variability for consistent outcomes.
  • Cell-based treatments for ON are safe and feasible, offering hope for improved patient management.