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The mutagenic source and power of our own evolution
1GMDx Group Ltd, Melbourne, VIC, Australia; Department of Clinical Pathology, Faculty of Medicine, Dentistry & Health Sciences, University of Melbourne, Melbourne, VIC, Australia.
Advances in Genetics
|October 21, 2020
Summary
This study explores how innate immunity enzymes, cytosine and adenosine deaminases, cause genetic mutations in mammals during development and disease. Understanding these deaminase-mediated mutations is key to unraveling cosmic genetic evolution.
Area of Science:
- Genetics
- Molecular Biology
- Immunology
Background:
- Genomes undergo numerous mutagenic changes during development and disease.
- Innate immunity plays a role in these genetic alterations.
Purpose of the Study:
- To review the molecular mechanisms and sources of genome mutations.
- To examine the role of innate immunity enzymes, specifically cytosine (AID/APOBEC) and adenosine (ADAR) deaminases, in mutagenesis.
Main Methods:
- Review of existing literature on deaminase-mediated mutagenesis.
- Analysis of the role of innate immunity in genetic variation.
Main Results:
- Cytosine (AID/APOBEC) and adenosine (ADAR) deaminases are central to mutagenic changes.
- Deaminase activity contributes to genetic diversity in mammalian genomes.
Conclusions:
- Deaminase-mediated mutagenesis is a general and universal process.
- Understanding these mechanisms is crucial for comprehending genetic evolution, including cosmic processes.
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