Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

5.9K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
5.9K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

9.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.5K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.2K
3.2K
RNA Splicing01:32

RNA Splicing

59.7K
Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
59.7K
The Ras Gene02:38

The Ras Gene

6.8K
The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...
6.8K
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

10.5K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
10.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Primary ciliogenesis is promoted during epithelial-mesenchymal transition via a miR-200 - DZIP1 axis.

Cell communication and signaling : CCS·2026
Same author

Strongly regulated transcription factors exert an outsized influence in microRNA-regulated networks.

Cell communication and signaling : CCS·2025
Same author

Chasing non-existent "microRNAs" in cancer.

Oncogenesis·2025
Same author

TRanscriptome ANalysis of StratifiEd CohorTs (TRANSECT) enables automated assessment of global gene regulation linked to disparate expression in user defined genes and gene sets.

NAR genomics and bioinformatics·2025
Same author

A Dual-Selection System for Enhanced Efficiency and Fidelity of Circular RNA Overexpression.

Journal of molecular biology·2025
Same author

Erratum to "RNA regulatory mechanisms controlling TGF-β signaling and EMT in cancer" [Semin. Cancer Biol. 102-103 (2024) 4-16].

Seminars in cancer biology·2024
Same journal

Escaping the trap.

Nature reviews. Cancer·2026
Same journal

A genomic and epigenomic lens into the biology of acute lymphoblastic leukaemia.

Nature reviews. Cancer·2026
Same journal

Systemic health impact of cancer-associated extracellular vesicles and particles.

Nature reviews. Cancer·2026
Same journal

Imaging the hallmarks of cancer.

Nature reviews. Cancer·2026
Same journal

CLIM-TIME links tumour genetics to spatial immune architecture.

Nature reviews. Cancer·2026
Same journal

Serving sulfur to boost anti-tumour immunity.

Nature reviews. Cancer·2026
See all related articles

Related Experiment Video

Updated: Dec 5, 2025

DNA Vector-based RNA Interference to Study Gene Function in Cancer
13:10

DNA Vector-based RNA Interference to Study Gene Function in Cancer

Published on: June 4, 2012

20.9K

RNA in cancer.

Gregory J Goodall1,2,3, Vihandha O Wickramasinghe4,5

  • 1Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA, Australia. greg.goodall@unisa.edu.au.

Nature Reviews. Cancer
|October 21, 2020
PubMed
Summary
This summary is machine-generated.

Altered RNA processing, including messenger RNA (mRNA) and non-coding RNAs, is increasingly linked to cancer development. Understanding these changes in RNA biogenesis is crucial for cancer research and therapy.

More Related Videos

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

916
Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes
08:32

Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes

Published on: May 23, 2025

862

Related Experiment Videos

Last Updated: Dec 5, 2025

DNA Vector-based RNA Interference to Study Gene Function in Cancer
13:10

DNA Vector-based RNA Interference to Study Gene Function in Cancer

Published on: June 4, 2012

20.9K
Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

916
Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes
08:32

Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes

Published on: May 23, 2025

862

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • RNA processing is vital for gene expression.
  • Aberrant RNA processing is a common feature in cancer.
  • Various RNA types, including coding and non-coding RNAs, are implicated in tumorigenesis.

Purpose of the Study:

  • To review how altered RNA processing and activity contribute to cancer.
  • To discuss established and emerging roles of different RNA subtypes in cancer.
  • To highlight mechanisms linking RNA biogenesis to cancer hallmarks.

Main Methods:

  • Literature review of recent findings on RNA processing in cancer.
  • Analysis of established and emerging roles of microRNAs, long non-coding RNAs, selective mRNA processing, and circular RNAs.
  • Discussion of molecular mechanisms underlying RNA's contribution to cancer.

Main Results:

  • Mutations in splicing factors and altered 3' untranslated regions are frequently observed in cancer.
  • Circular RNAs and other non-coding RNAs play significant roles in tumorigenesis.
  • Altered RNA biogenesis contributes to multiple hallmarks of cancer.

Conclusions:

  • Dysregulation of both coding and non-coding RNA processing is a significant factor in cancer.
  • Targeting RNA processing pathways represents a potential therapeutic strategy.
  • Further research into RNA's role in cancer is warranted.