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Related Experiment Video

Updated: Dec 5, 2025

Aortic Ring Assay

Aortic Ring Assay

Published on: November 24, 2009

Hot Aortic Nodules.

Erik Soule¹, Quoc-Han Nguyen¹, Mario Dervishi¹

¹Interventional Radiology, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.

|October 21, 2020

Summary

Positron emission tomography can detect 18-fluorodeoxyglucose uptake in atherosclerotic plaques. This finding may help identify high-risk patients for cardiovascular disease, enabling early intervention.

Keywords:

atherosclerotic cardiovascular disease cerebrovascular accident (stroke)fluorodeoxyglucose positron emission tomography inflammatory plaques myocardial infarction plaque rupture

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Area of Science:

Cardiovascular Medicine
Nuclear Medicine
Radiology

Background:

Atherosclerotic cardiovascular disease (ASCVD) is a major global health concern, leading to severe thrombotic complications like stroke and heart attack.
Early identification of aggressive ASCVD is crucial for effective risk stratification and treatment planning.

Observation:

This report details four patients where 18-fluorodeoxyglucose (FDG) uptake was observed in atherosclerotic plaques during positron emission tomography (PET) scans.
These PET scans were initially performed for indications unrelated to atherosclerosis detection.

Findings:

The study highlights the potential for FDG-avid atherosclerotic plaques to be incidentally discovered via PET imaging.
This incidental finding suggests a potential imaging biomarker for active or high-risk atherosclerosis.

Implications:

Detecting FDG-avid plaques could facilitate earlier diagnosis and intervention for ASCVD.
This may lead to improved patient outcomes through intensified lifestyle changes, medication, or procedures like endovascular atherectomy.