The Strategies of Pathogen-Oriented Therapy on Circumventing Antimicrobial Resistance

Area of Science:

• Microbiology
• Infectious Diseases
• Pharmacology

Background:

• Antimicrobial resistance (AMR) is a critical global health threat, diminishing the effectiveness of conventional antibiotics.
• The pipeline for novel antibiotic development is insufficient to combat escalating drug-resistant bacterial infections.
• Urgent need exists for alternative therapeutic strategies to address the AMR crisis.

Purpose of the Study:

• To review recent advancements in pathogen-oriented therapy (POT) as a strategy to circumvent antimicrobial resistance.
• To highlight various POT approaches and their potential in combating drug-resistant bacteria.

Main Methods:

• Review of current literature on emerging therapeutic strategies for AMR.
• Exemplification of recent trends in pathogen-oriented therapy (POT).
• Discussion of specific POT modalities including conjugates, peptides, antibodies, nanotech, CRISPR-Cas, and microbiota modulation.

Main Results:

• Pathogen-oriented therapy (POT) involves targeted application of antibacterial agents to infected sites.
• POT aims to enhance drug efficacy and minimize off-target effects and resistance development.
• Various POT approaches, including antibiotic-antibiotic conjugates, antimicrobial peptides, therapeutic monoclonal antibodies, nanotechnologies, CRISPR-Cas systems, and microbiota modulations, show promise.

Conclusions:

• Pathogen-oriented therapy (POT) presents a viable and promising approach to address the challenge of antimicrobial resistance.
• The reviewed POT strategies offer advantages over conventional treatments for drug-resistant bacterial infections.
• Combined or individual application of these alternative approaches can effectively combat the growing clinical challenge of antibiotic resistance.