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Aspergillosis Complicating Severe Coronavirus Disease
Emerging Infectious Diseases
|October 21, 2020
Summary
Pulmonary aspergillosis complicating severe influenza and COVID-19 (CAPA) presents unique challenges distinct from classic invasive aspergillosis. Early diagnosis and intervention are crucial for improving outcomes in these critically ill patients.
Area of Science:
- * Pulmonology and Infectious Diseases
- * Mycology and Critical Care Medicine
Background:
- * Increasing global detection of aspergillosis complicating severe influenza infections.
- * Emergence of coronavirus disease-associated pulmonary aspergillosis (CAPA) reported globally, particularly in Europe.
- * Pulmonary aspergillosis in viral infections differs from classic invasive aspergillosis in immunocompromised individuals.
Purpose of the Study:
- * To present a case series of 20 patients with CAPA.
- * To review the pathophysiology, diagnosis, and outcomes of CAPA.
- * To highlight the distinct clinical syndromes and risks associated with viral-associated pulmonary aspergillosis.
Main Methods:
- * Retrospective case series analysis of 20 CAPA patients.
- * Literature review on pathophysiology, diagnosis, and outcomes.
- * Analysis of clinical presentations, radiological findings, and treatment responses.
Main Results:
- * CAPA involves a combination of airway-invasive and angio-invasive aspergillosis.
- * Pathophysiology linked to impaired fungal clearance due to viral infection, epithelial damage, immunosuppression, and lung disease.
- * Varied radiological abnormalities observed, reflecting diverse pathologies.
Conclusions:
- * CAPA represents a distinct syndrome requiring specific diagnostic and therapeutic strategies.
- * Poor outcomes reported in CAPA underscore the need for improved management approaches.
- * Urgent development of improved diagnostic, preventive, and therapeutic strategies for CAPA is essential.
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