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Author Spotlight: A Cost-Effective Genomic Workflow for Advancing Rabies Control in Resource-Limited Settings
Published on: August 18, 2023
Genome sequencing and phylogenetic reconstruction reveal a potential fourth rhinovirus species and its worldwide
Kim Tien Ng1,2, Yutaka Takebe3,4, Adeeba Kamarulzaman1
1Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Abstract:
Genome sequences of members of a potential fourth rhinovirus (RV) species, provisionally denoted as rhinovirus A clade D, from patients with acute respiratory infection were determined. Bayesian coalescent analysis estimated that clade D emerged around the 1940s and diverged further around 2006-2007 into two distinctive sublineages (RV-A8-like and RV-A45-like) that harbored unique "clade-defining" substitutions. Similarity plots and bootscan mapping revealed a recombination breakpoint located in the 5'-UTR region of members of the RV-A8-like sublineage. Phylogenetic reconstruction revealed the distribution of clade D viruses in the Asia Pacific region and in Europe, underlining its worldwide distribution.
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