A Novel Insight into the Ozone-Skin Lipid Oxidation Products Observed by Secondary Electrospray Ionization...

Emissions of secondary products through reactions of oxidants, ozone (O₃), and hydroxyl radical (·OH) with human skin lipids have become increasingly important in indoor environments. Here, we evaluate the secondary organic compounds formed through heterogeneous reactions of gaseous O₃ with hand skin lipids by using a high-resolution quadrupole Orbitrap mass spectrometer coupled to a commercial secondary electrospray ionization (SESI) source. More than 600 ions were detected over a period of less than 40 min real-time measurements, among which 53 ions were characterized with a significant increasing trend in signal intensity at the presence of O₃. Based on the detected ions, we suggest detailed reaction pathways initiated by ozone oxidation of squalene that results in primary and secondary ozonides; we noticed for the first time that these products may be further cleaved by direct reaction of nucleophilic ammonia (NH₃), emitted from human skin. Finally, we estimate the fate of secondarily formed carbonyl compounds with respect to their gas-phase reactions with ·OH, O₃, and NO₃ and compared with their removal by air exchange rate (AER) with outdoors. The obtained results suggest that human presence is a source of an important number of organic compounds, which can significantly influence the air quality in indoor environments.