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Label-Free Optical Resonator-Based Biosensors.

Donggee Rho1, Caitlyn Breaux1, Seunghyun Kim1

  • 1Electrical and Computer Engineering Department, Baylor University, One Bear Place #97356, Waco, TX 76798, USA.

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Summary
This summary is machine-generated.

Optical resonator biosensors offer sensitive, label-free detection for diagnostics. This review covers recent advances in Fabry-Perot interferometer and whispering gallery mode biosensor technologies.

Keywords:
Fabry-Perot interferometerlabel-free biosensorsoptical resonatorswhispering gallery mode resonators

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Area of Science:

  • Biomedical Engineering
  • Optics
  • Nanotechnology

Background:

  • Biosensor technology demand is rising for disease diagnosis, drug development, and environmental monitoring.
  • Optical resonator biosensors provide sensitive, rapid, label-free detection of biological analytes.
  • Microfluidics and micro/nanofabrication enable miniaturized, multi-analyte detection in small volumes.

Purpose of the Study:

  • To review recent advancements in label-free optical resonator-based biosensors.
  • To categorize biosensors into Fabry-Perot interferometer-based and whispering gallery mode-based types.
  • To discuss progress in configurations, materials, test setups, and light confinement.

Main Methods:

  • Literature review focusing on publications from the last 5 years.
  • Categorization based on optical resonator principles: Fabry-Perot interferometers and whispering gallery modes.
  • Analysis of recent developments in biosensor design and application.

Main Results:

  • Optical resonator biosensors are crucial for medical diagnostics and point-of-care applications.
  • Recent progress has been made in enhancing sensitivity, speed, and miniaturization.
  • Both Fabry-Perot interferometer and whispering gallery mode biosensors show significant development.

Conclusions:

  • Optical resonator biosensors represent a promising platform for advanced diagnostics.
  • Continued research in materials and fabrication will further enhance biosensor capabilities.
  • Future work should address current challenges to optimize performance and expand applications.