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Updated: Dec 4, 2025
MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method
Published on: October 7, 2025
Focus on MicroRNAs as Biomarker in Pediatric Diseases
Giuseppe Lassandro1, Loredana Ciaccia1, Anna Amoruso1
1Department of Biomedical Science and Human Oncology, University of Bari "Aldo Moro", Bari, Italy.
Background:
MiRNAs are a class of small non-coding RNAs that are involved in the post-transcriptional regulation of gene expression. MiRNAs are considered a class of epigenetic biomarkers. These biomarkers can investigate disease at different stages: diagnosis, therapy or clinical follow-up.
Objective:
The aim of this paper is to highlight the innovative use of miRNAs in several childhood diseases.
Methods:
We conducted a literature review to search the usage of miRNAs in pediatric clinical routine or experimental trials.
Results:
We found a possible key role of miRNAs in different pediatric illnesses (metabolic alterations, coagulation defects, cancer).
Conclusion:
The modest literature production denotes that further investigation is needed to assess and validate the promising role of miRNAs as non-invasive biomarkers in pediatric disorders.
