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[Retrospect and perspective in rhinologic allergology].

¹Universitätsklinik und Poliklinik für Hals-, Nasen- und Ohrenkranke im Kopfklinikum Würzburg.

|August 1, 1987

Summary

Allergic rhinitis, first described in 1819, was later understood through the discovery of immunoglobulin E (IgE) antibodies. This breakthrough integrated nasal allergy into clinical immunology.

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Area of Science:

Immunology
Allergology
Clinical Medicine

Context:

The historical understanding of allergic rhinitis evolved significantly from its initial description in 1819.
Early researchers like Blackley established the etiology, while Pirquet introduced the concept of "allergy" in 1906.
The Prausnitz-Kustner experiment in 1922 demonstrated the transfer of immediate hypersensitivity via serum, identifying "atopic reagin."

Purpose:

To trace the historical development of understanding allergic rhinitis and hypersensitivity.
To highlight key discoveries that led to the identification of specific antibodies involved in allergic reactions.
To explain how these discoveries facilitated the integration of nasal allergy into the field of clinical immunology.

Summary:

John Bostock provided the first description of allergic rhinitis in 1819.
The concept of allergy was introduced by Clemens von Pirquet in 1906, linking hypersensitivity and immunity.
A pivotal moment was the 1967 discovery of immunoglobulin E (IgE) antibodies by Ishizaka and Ishizaka, confirming their role as reaginic antibodies and enabling the classification of nasal allergy within clinical immunology.

Impact:

The identification of IgE antibodies revolutionized the understanding of allergic diseases.
This knowledge paved the way for advancements in diagnosing and managing allergic rhinitis.
The integration into clinical immunology established a framework for studying and treating allergic conditions.

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