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Updated: Dec 4, 2025

Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications
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First small-molecule PROTACs for G protein-coupled receptors: inducing α 1A-adrenergic receptor degradation

Zhenzhen Li1, Yuxing Lin1, Hui Song2

  • 1Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Shandong University, Jinan 250012, China.

Acta Pharmaceutica Sinica. B
|October 22, 2020
PubMed

Keywords:
BPH, benign prostatic hyperplasiaCRBN, cereblonDCM, dichloromethaneDMF, dimethylformamideDMSO, dimethylsulfoxideDegradationGPCR, G-protein-coupled receptorHPLC, high-performance liquid chromatographyLUTS, lower urinary tract symptomsPROTACs, proteolysis targeting chimerasProstate cancerSmall-molecule PROTACsTEA, triethylamineTHF, tetrahydrofuranUbiquitylationhPCE, human prostate cancer epithelialα1-ARs, α1-adrenergic receptorsα1A-AR, α1A-adrenergic receptorα1A-Adrenergic receptorα1B-AR, α1B-adrenergic receptorα1D-AR, α1D-adrenergic receptor

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