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Video-oculography in Mice

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Human Vestibulo-Ocular Reflex Adaptation Reduces when Training Demand Variability Increases.

Carlo N Rinaudo^1,2, Michael C Schubert^3,4, William V C Figtree^1,2

¹Balance and Vision Laboratory, Neuroscience Research Australia, Cnr Barker Street & Easy Street, Randwick, NSW, 2031, Australia.

Journal of the Association for Research in Otolaryngology : JARO

|October 22, 2020

Summary

This summary is machine-generated.

Variability in home-based vestibular exercises impacts vestibulo-ocular reflex (VOR) adaptation. Manual gaze-stabilizing exercises showed less VOR adaptation in patients due to higher training variability, suggesting current methods may be weak stimuli.

Keywords:

VOR adaptation incremental frequency adaptation variability of training demand vestibular rehabilitation gaze-stabilizing exercises vestibulo-ocular reflex (VOR)× 1 and × 2 training

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Area of Science:

Neuroscience
Ophthalmology
Rehabilitation Medicine

Background:

Vestibular rehabilitation for vestibulo-ocular reflex (VOR) hypofunction uses gaze-stabilizing exercises.
Home-based exercises introduce training variability, potentially affecting VOR adaptation.
The efficacy of variable manual exercises versus non-variable computer-controlled exercises requires investigation.

Purpose of the Study:

To investigate the effect of training variability on VOR adaptation in healthy controls and patients with unilateral vestibular hypofunction.
To compare VOR adaptation between manual (variable) and computer-controlled (non-variable) gaze-stabilizing exercises.
To assess the efficacy of clinical gaze-stabilizing exercises for VOR adaptation.

Main Methods:

Ten healthy controls and ten patients with unilateral vestibular hypofunction performed manual gaze-stabilizing exercises (x1 and x2 training).
Head rotation frequency increased from 0.5-2 Hz over 20 minutes during training.
Active and passive VOR gains (sinusoidal and head impulse) were measured pre- and post-training.

Main Results:

Healthy controls showed significant VOR adaptation (sinusoidal ~6%, impulse ~3%) with manual x2 training, but lower than non-variable computer-controlled training.
Patients exhibited increased impulse VOR but not sinusoidal VOR after manual x2 training.
Patients demonstrated over double the VOR demand variability compared to controls during manual x2 training.

Conclusions:

Training variability in manual gaze-stabilizing exercises may hinder VOR adaptation, particularly in patients with vestibular hypofunction.
Clinical x1 gaze-stabilizing exercises appear to be a weak stimulus for VOR adaptation.
Optimizing exercise protocols to minimize variability may enhance VOR rehabilitation outcomes.