Complete Coding Sequence of a Lumpy Skin Disease Virus from an Outbreak in Bulgaria in 2016

Area of Science:

• Veterinary Virology
• Emerging Infectious Diseases
• Genomics

Background:

• Lumpy skin disease (LSD) poses a growing threat to cattle populations globally.
• The disease causes significant economic losses in the livestock industry.
• Understanding the genetic makeup of LSD virus strains is crucial for disease control.

Purpose of the Study:

• To sequence and characterize the complete coding region of a Lumpy skin disease virus isolate.
• To provide genetic data from a specific LSD outbreak in Bulgaria.
• To contribute to the genomic surveillance of Lumpy skin disease virus.

Main Methods:

• Viral DNA extraction from a blood sample of an infected cow.
• Whole-genome sequencing to determine the complete coding sequence.
• Bioinformatic analysis of the obtained viral genome.

Main Results:

• The complete coding sequence of the Lumpy skin disease virus strain 210LSD-249/BUL/16 was successfully determined.
• The virus was identified in a blood sample collected during a 2016 outbreak in Bulgaria.
• This provides valuable genomic information on a European LSDV isolate.

Conclusions:

• The availability of this complete LSD virus genome sequence aids in molecular epidemiology.
• Further genomic studies are essential for tracking LSDV evolution and spread.
• This data supports the development of diagnostic and control strategies for Lumpy skin disease.