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Circular RNA expression profiles significantly altered in UVA-irradiated human dermal fibroblasts

Mengbi Lin1, Yue Zheng1, Qian Li1

  • 1Department of Dermatology and Venereology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China.

Experimental and Therapeutic Medicine
|October 23, 2020
PubMed

Insights

This study reveals that ultraviolet A (UVA) radiation alters circular RNA (circRNA) expression in skin cells. These findings offer new insights into the mechanisms of photoaging and potential therapeutic targets for skin diseases.

Area of Science:

  • Molecular Biology
  • Dermatology
  • Genetics

Background:

  • Circular RNAs (circRNAs) are increasingly recognized for their roles in various diseases.
  • The specific involvement of circRNAs in skin photoaging is not well understood.

Purpose of the Study:

  • To investigate the impact of ultraviolet A (UVA) irradiation on circRNA expression in human dermal fibroblasts.
  • To identify specific circRNAs and pathways affected by UVA exposure relevant to photoaging.

Main Methods:

  • Profiling of circRNA expression in human dermal fibroblasts after UVA irradiation.
  • Bioinformatic analysis including Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis.

Main Results:

  • A total of 128 differentially expressed circRNAs were identified following UVA exposure (1.5-fold change; P<0.05).
  • Of these, 39 circRNAs were upregulated and 89 were downregulated.
  • Pathway analysis linked these circRNAs to extracellular matrix organization and metabolism.

Conclusions:

  • UVA irradiation significantly alters the circRNA expression profile in dermal fibroblasts.
  • These findings provide a foundation for understanding the molecular mechanisms of skin photoaging.
  • The identified circRNAs represent potential targets for preventing and treating photoaging and related skin conditions.
Keywords:
circular RNAextracellular matrixfibroblastmicroRNAphotoagingultraviolet A

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