Comparative Findings Between ⁶⁸Ga-PSMA and ¹⁸F-FDG PET/CT for Hepatocellular Carcinoma

We have reported here the case of a 69-year-old man who presented with spinal cord compression due to bone metastases as the first manifestation of hepatocellular carcinoma (HCC). For the initial staging, the patient underwent ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography/computerized tomography (PET/CT) imaging, which demonstrated mild ¹⁸F-FDG uptake in the multiple expansile osteolytic bone lesions, but no remarkable atypical ¹⁸F-FDG uptake in the liver lesion on low-doses CT. An additional PET/CT scan was performed to evaluate the prostate-specific membrane antigen (PSMA) expression, which has recently been reported to be a potential biological marker in a variety of tumors including HCC. High PSMA uptake was recorded in both the metastatic bone lesions and the primary liver lesion/tumor by the ⁶⁸Ga-PSMA PET/CT.