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Updated: Dec 4, 2025
09:14
Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
Published on: September 28, 2022
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EBV : not your Everyday Benign Virus.
H Ruymbeke1, J Schouten2, F Sermon3
1Department of Gastroenterology, Ghent University, Ghent, Belgium.
Acta Gastro-Enterologica Belgica
|October 23, 2020
Summary
Epstein-Barr virus (EBV) infection, commonly causing mononucleosis, can rarely lead to spontaneous splenic rupture. Early recognition of EBV symptoms and abdominal pain is crucial for prompt diagnosis and management.
Area of Science:
- Virology
- Infectious Diseases
- Internal Medicine
Background:
- Epstein-Barr virus (EBV) infection is highly prevalent, affecting 90% of adults.
- Primary EBV infection presentations vary, often being subclinical or manifesting as infectious mononucleosis.
- While typically benign, EBV can lead to severe complications.
Observation:
- A 19-year-old female presented with malaise, fever, dyspnea, jaundice, vomiting, diarrhea, and left upper quadrant pain.
- The patient was diagnosed with acute EBV infection, hepatitis, and splenomegaly.
- She experienced a spontaneous splenic rupture.
Findings:
- Spontaneous splenic rupture is a rare but life-threatening complication of infectious mononucleosis.
- Acute EBV infection can present with hepatitis and significant splenomegaly, increasing rupture risk.
- The case highlights the potential severity of EBV-related complications.
Implications:
- Clinicians should consider spontaneous splenic rupture in EBV-suspected patients with abdominal pain.
- Prompt diagnosis and management are vital for improving outcomes in EBV-related splenic rupture.
- Awareness and patient counseling regarding potential EBV complications are essential.
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