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Arterial fibromuscular dysplasia
T F Lüscher1, J T Lie, A W Stanson
1Department of Physiology and Biophysics, Mayo Clinic, Rochester, MN 55905.
Mayo Clinic Proceedings
|October 1, 1987
Summary
Fibromuscular dysplasia is a vascular condition affecting arteries like the renal and carotid. While its cause is unclear, angioplasty is the preferred treatment for symptomatic patients.
Area of Science:
- Vascular Medicine
- Cardiology
- Genetics
Background:
- Fibromuscular dysplasia (FMD) is a nonatherosclerotic, noninflammatory vascular condition.
- It predominantly affects the renal and internal carotid arteries, but can also involve vertebral, iliac, subclavian, and visceral arteries.
- The exact pathogenesis remains incompletely understood, with potential contributions from humoral, mechanical, genetic factors, and mural ischemia.
Purpose of the Study:
- To summarize the key aspects of fibromuscular dysplasia, including its affected arteries, pathogenesis, natural history, clinical manifestations, and treatment.
Main Methods:
- This abstract synthesizes information from existing literature on fibromuscular dysplasia.
- It reviews the epidemiology, etiology, clinical presentation, and management strategies for FMD.
- Focus is placed on characteristic arterial involvement and common symptoms.
Main Results:
- Fibromuscular dysplasia typically affects the renal and internal carotid arteries.
- The disease progression is generally benign, with a minority of patients experiencing advancement.
- Clinical manifestations include renovascular hypertension, stroke, subarachnoid hemorrhage, abdominal angina, and limb claudication.
Conclusions:
- Fibromuscular dysplasia is a distinct vascular disease with varied arterial involvement.
- Percutaneous transluminal angioplasty is the primary treatment for symptomatic individuals across affected vascular beds.
- Further research into its pathogenesis may elucidate more targeted therapeutic approaches.