Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Design Example: Automobile Ignition System01:14

Design Example: Automobile Ignition System

440
The automobile's ignition system plays a vital role by ensuring the timely ignition of the fuel-air mixture in each cylinder. This ignition is facilitated by a spark plug, which is composed of two electrodes separated by an air gap. A spark forms across this air gap when a substantial voltage is generated between the electrodes, leading to the ignition of the fuel.
One can generate a large voltage using a car battery of 12 volts with the help of inductors. Inductors are known for opposing...
440
Internal Combustion Engine01:20

Internal Combustion Engine

2.2K
The internal combustion engine is a heat engine that uses the byproducts of combustion as the working fluid instead of using a heat transfer medium to transfer heat. The combustion is done in a way that produces high-pressure combustion products that can be expanded through a turbine or piston to create work. Internal combustion engines can again be categorized into three kinds: (1) spark ignition gasoline engines, most commonly used in automobiles, (2) compression ignition diesel engines that...
2.2K
Design of Transmission Shafts01:16

Design of Transmission Shafts

623
The design of a transmission shaft is governed by two primary specifications: the power it transmits and its rotational speed. These parameters guide the selection of the shaft's material and cross-sectional dimensions, ensuring that the material's maximum shearing stress remains within the elastic limit while transmitting the desired power at the given speed. The system's power is intrinsically linked to the applied torque. The torque applied to the shaft can be calculated by reconfiguring the...
623
Steps in the Modeling Process01:14

Steps in the Modeling Process

512
Albert Bandura's theory of observational learning identifies four critical processes: attention, retention, motor reproduction, and reinforcement or motivation.
Attention is the first necessary component for observational learning. It involves focusing on what the model is doing and saying. For example, if you decide to take a drawing class to enhance your skills, you need to pay close attention to the instructor's words and hand movements. The characteristics of the model significantly...
512
Clearance Models: Compartment Models01:25

Clearance Models: Compartment Models

218
Clearance measures drug elimination from the central compartment, including plasma and highly perfused organs like kidneys and liver. Its calculation varies depending on pharmacokinetic models and administration routes. The one-compartment model, for instance, portrays the pharmacokinetics of polar drugs such as aminoglycoside antibiotics administered intravenously and readily excreted in urine. In this case, clearance is influenced by the terminal rate constant (λz) and the total volume...
218
Rolling Resistance: Problem Solving01:17

Rolling Resistance: Problem Solving

666
Rolling resistance, also known as rolling friction, is the force that resists the motion of a rolling object, such as a wheel, tire, or ball, when it moves over a surface. It is caused by the deformation of the object and the surface in contact with each other, as well as other factors like internal friction, hysteresis, and energy losses within the materials. Rolling resistance opposes the object's motion, requiring additional energy to overcome it and maintain movement. In practical...
666

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Regenerative macrophages enhance stem cell-derived β cell function and engraftment.

Science advances·2026
Same author

Engineering human T cells with antigen receptors for immune regulation in autoimmune disease and transplantation.

Molecular therapy : the journal of the American Society of Gene Therapy·2026
Same author

Reproducible detection of antigen-specific T cells and Tregs via standardized and automated activation-induced marker assay workflows.

Cell reports methods·2026
Same author

Human and mouse regenerative macrophages enhance beta cell survival, function, and proliferation.

Islets·2026
Same author

Beta Integrin Expression Defines Functionally Distinct CD4<sup>+</sup> T-Cell Subsets That Are Altered in Ulcerative Colitis.

Gastro hep advances·2026
Same author

Chronic graft-versus-host disease suppressing CD56<sup>bright</sup>Perforin<sup>neg</sup> regulatory-like NK cells inhibit CD4<sup>+</sup> T cells via PD-1, LAG-3, and TRAIL.

Cytotherapy·2026

Related Experiment Video

Updated: Dec 4, 2025

Structural Design and Manufacturing of a Cruiser Class Solar Vehicle
14:57

Structural Design and Manufacturing of a Cruiser Class Solar Vehicle

Published on: January 30, 2019

14.2K

Building a CAR-Treg: Going from the basic to the luxury model.

Isaac Rosado-Sánchez1, Megan K Levings2

  • 1BC Children's Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada; School of Biomedical Engineering, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.

Cellular Immunology
|October 23, 2020
PubMed
Summary

Chimeric antigen receptor (CAR)-Tregs offer promising cell therapy for autoimmune diseases. Engineering these regulatory T cells (Tregs) with CARs enhances their specificity and therapeutic potential for improved immune control.

Keywords:
AutoimmunityChimeric Antigen ReceptorRegulatory T cellsSignalingToleranceTransplantation

More Related Videos

A Rapid Method for Modeling a Variable Cycle Engine
04:58

A Rapid Method for Modeling a Variable Cycle Engine

Published on: August 13, 2019

7.9K
The Modular Design and Production of an Intelligent Robot Based on a Closed-Loop Control Strategy
11:53

The Modular Design and Production of an Intelligent Robot Based on a Closed-Loop Control Strategy

Published on: October 14, 2017

12.0K

Related Experiment Videos

Last Updated: Dec 4, 2025

Structural Design and Manufacturing of a Cruiser Class Solar Vehicle
14:57

Structural Design and Manufacturing of a Cruiser Class Solar Vehicle

Published on: January 30, 2019

14.2K
A Rapid Method for Modeling a Variable Cycle Engine
04:58

A Rapid Method for Modeling a Variable Cycle Engine

Published on: August 13, 2019

7.9K
The Modular Design and Production of an Intelligent Robot Based on a Closed-Loop Control Strategy
11:53

The Modular Design and Production of an Intelligent Robot Based on a Closed-Loop Control Strategy

Published on: October 14, 2017

12.0K

Area of Science:

  • Immunology
  • Cell Therapy
  • Biotechnology

Background:

  • Regulatory T cells (Tregs) are crucial for maintaining immune homeostasis and preventing excessive immune responses.
  • Treg cell therapy shows potential for treating autoimmune and autoinflammatory conditions.
  • Enhancing Treg specificity, particularly through antigen-specificity, significantly improves therapeutic efficacy.

Purpose of the Study:

  • To review key considerations for generating Chimeric Antigen Receptor (CAR)-Tregs.
  • To explore strategies for optimizing CAR-Treg function by leveraging advances in CAR-T cell therapy.
  • To discuss the development of advanced CAR-Treg models for refined immune modulation.

Main Methods:

  • Review of current literature on CAR-Treg development.
  • Extrapolation of findings from CAR-T cell research for CAR-Treg optimization.
  • Analysis of strategies to enhance CAR-Treg structure and function.

Main Results:

  • Proof-of-concept studies demonstrate the feasibility of basic CAR-Treg therapy for autoimmunity and transplantation.
  • Advances in CAR-T cell technology offer insights into improving CAR-Treg potency and precision.
  • Key considerations for CAR-Treg generation are being identified.

Conclusions:

  • CAR-Tregs represent a powerful tool for antigen-specific immunotherapy.
  • Optimizing CAR-Treg design, informed by CAR-T cell research, can lead to more effective "luxury" Treg models.
  • Further development of CAR-Tregs holds significant promise for treating immune-mediated diseases.