Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

2.3K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
2.3K
Cell Migration01:19

Cell Migration

6.0K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
6.0K
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

1.4K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nuclear proteome reveals microtubule-associated protein regulating fate and disease.

Cell·2026
Same author

Developmental gene expression patterns driving species-specific cortical features.

Nature·2026
Same author

Position-independent emergence of neocortical neuron molecular identity, connectivity and function.

Nature neuroscience·2025
Same author

P2X purinergic receptors are required for correct cortical development in human brain organoids.

Neuropharmacology·2025
Same author

Modelling human adult V-SVZ niche assembly and ependymal cell generation in brain organoids.

EMBO reports·2025
Same author

Fundamental Neurochemistry Review: Sphingolipids and Ceramides in Brain Development.

Journal of neurochemistry·2025
Same journal

Population codes for context-dependent decision-making.

Current opinion in neurobiology·2026
Same journal

Cichlid fish as a model for understanding social dysfunction.

Current opinion in neurobiology·2026
Same journal

On aims and methods in field neuroethology: Investigating neural mechanisms of behavior in semi-natural and natural contexts.

Current opinion in neurobiology·2026
Same journal

Neurobiological interfaces connecting environmental change to monarch butterfly migration.

Current opinion in neurobiology·2026
Same journal

Learning how to experience the world: From circuits to cell types to genes.

Current opinion in neurobiology·2026
Same journal

Editorial overview for neurobiology of disease 2026.

Current opinion in neurobiology·2026
See all related articles

Related Experiment Video

Updated: Dec 4, 2025

Migratory Behavior of Cells Generated in Ganglionic Eminence Cultures
06:34

Migratory Behavior of Cells Generated in Ganglionic Eminence Cultures

Published on: April 21, 2011

10.4K

Neuronal migration and disorders - an update.

Fiona Francis1, Silvia Cappello2

  • 1INSERM U 1270, Paris, France; Sorbonne University, UMR-S 1270, F-75005 Paris, France; Institut du Fer à Moulin, Paris, France.

Current Opinion in Neurobiology
|October 23, 2020
PubMed
Summary
This summary is machine-generated.

Disruptions in microtubule and actin cytoskeletons, adhesion molecules, and signaling pathways underlie cortical neuronal migration disorders. Understanding these mechanisms is crucial for developing treatments for these complex neurological conditions.

More Related Videos

Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons
09:50

Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons

Published on: April 20, 2018

10.3K
Nucleofection of Rodent Neuroblasts to Study Neuroblast Migration In vitro
11:32

Nucleofection of Rodent Neuroblasts to Study Neuroblast Migration In vitro

Published on: November 12, 2013

11.7K

Related Experiment Videos

Last Updated: Dec 4, 2025

Migratory Behavior of Cells Generated in Ganglionic Eminence Cultures
06:34

Migratory Behavior of Cells Generated in Ganglionic Eminence Cultures

Published on: April 21, 2011

10.4K
Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons
09:50

Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons

Published on: April 20, 2018

10.3K
Nucleofection of Rodent Neuroblasts to Study Neuroblast Migration In vitro
11:32

Nucleofection of Rodent Neuroblasts to Study Neuroblast Migration In vitro

Published on: November 12, 2013

11.7K

Area of Science:

  • Neuroscience
  • Cell Biology
  • Developmental Biology

Background:

  • Cortical neuronal migration is essential for proper brain development.
  • Disruptions in this process lead to various neurological disorders.
  • The microtubule cytoskeleton plays a critical role in neuronal migration.

Purpose of the Study:

  • To review recent advances in understanding cortical neuronal migration.
  • To highlight genetic and subcellular mechanisms influencing neuronal migration.
  • To present current views on disrupted mechanisms in migration disorders.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of findings from human in vitro models.
  • Examination of data from model organisms, including cell-type specific knockouts/knockins.
  • Integration of omics and functional data.

Main Results:

  • Microtubule (MT) cytoskeleton alterations significantly impact neuronal migration.
  • Disruptions involve centrosomal, microtubule-associated, and motor proteins.
  • Other factors like actin cytoskeleton, extracellular matrix, adhesion molecules, and signaling pathways are also implicated, particularly in disorders like periventricular heterotopia.

Conclusions:

  • Multiple subcellular mechanisms, including cytoskeletal dynamics and signaling pathways, are critical for cortical neuronal migration.
  • Dysregulation of these mechanisms underlies diverse neuronal migration disorders.
  • Integrated approaches using advanced models and data are essential for a comprehensive understanding.