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Lymph Node Stromal Cells: Mapmakers of T Cell Immunity

Guillaume Harlé1, Camille Kowalski1, Laure Garnier1

  • 1Department of Pathology and Immunology, School of Medicine, University of Geneva, 1206 Geneva, Switzerland.

International Journal of Molecular Sciences
|October 24, 2020
PubMed

Stromal cells (SCs) are strategically positioned in both lymphoid and nonlymphoid organs to provide a scaffold and orchestrate immunity by modulating immune cell maturation, migration and activation. Recent characterizations of SCs have expanded our understanding of their heterogeneity and suggested a functional specialization of distinct SC subsets, further modulated by the microenvironment. Lymph node SCs (LNSCs) have been shown to be particularly important in maintaining immune homeostasis and T cell tolerance. Under inflammation situations, such as viral infections or tumor development, SCs undergo profound changes in their numbers and phenotype and play important roles in contributing to either the activation or the control of T cell immunity. In this review, we highlight the role of SCs located in LNs in shaping peripheral T cell responses in different immune contexts, such as autoimmunity, viral and cancer immunity.

Keywords:
T cellsalloimmunityautoimmunitycancerlymph node stromal cellsviral infection

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