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Ceruloplasmin and Coronary Heart Disease-A Systematic Review

Antonio P Arenas de Larriva1,2, Laura Limia-Pérez1,2, Juan F Alcalá-Díaz1,2

  • 1Lipids and Atherosclerosis Unit, Department of Internal Medicine, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Av. Menendez Pidal s/n, 14004 Cordoba, Spain.

Nutrients
|October 24, 2020
PubMed

Insights

Elevated ceruloplasmin levels are linked to increased coronary heart disease risk. Further research is needed to confirm ceruloplasmin

Area of Science:

  • Cardiovascular Medicine
  • Biochemistry
  • Epidemiology

Background:

  • Oxidative stress is implicated in cardiovascular diseases.
  • The role of ceruloplasmin in cardiovascular disease pathogenesis is unclear, with debate on whether it's a marker or mediator.
  • Understanding ceruloplasmin's impact on cardiovascular disease risk is crucial.

Purpose of the Study:

  • To assess the association between ceruloplasmin blood levels and cardiovascular disease risk, specifically coronary heart disease.
  • To synthesize evidence from observational studies on ceruloplasmin and coronary heart disease incidence.
  • To identify research gaps regarding ceruloplasmin's function and therapeutic potential.

Main Methods:

  • Systematic literature search of Medline via PubMed and EMBASE.
  • Inclusion of observational studies in the general adult population.
  • Quality assessment of eligible studies using US Preventive Services Task Force criteria.

Main Results:

  • Most of the 18 reviewed studies suggest a positive correlation between higher ceruloplasmin levels and increased coronary heart disease incidence.
  • Evidence points towards a potential direct relationship between elevated ceruloplasmin and coronary heart disease risk.
  • The reviewed studies highlight the need for further investigation into ceruloplasmin's specific role.

Conclusions:

  • Elevated ceruloplasmin levels appear associated with an increased risk of coronary heart disease.
  • Clinical trials are warranted to elucidate ceruloplasmin's mediating functions in coronary heart disease development.
  • Further research should evaluate the therapeutic implications of managing elevated ceruloplasmin levels for cardiovascular disease prevention and prognosis.

Keywords:
ceruloplasmincoronary heart diseaseinflammation

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