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[Determination of blood ceftriaxone. Comparison of microbiological and HPLC methods]
B de Barbeyrac1, F Penouil, J J Gardère
1Laboratoire de Bactériologie, Hôpital Pellegrin, Bordeaux.
Pathologie-Biologie
|June 1, 1987
Abstract:
108 serum samples in 27 patients were collected after the first, before the second, after and before the fifth dose of 2 g every 24 h and assayed for ceftriaxone by microbiological method and high pressure liquid chromatography (HPLC). The statistical analysis of the results show a correlation coefficient equal to 0.95. The protein binding doesn't affect the microbiological method. The two methods are convenient for clinical use.