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Protocols for Testing the Toxicity of Novel Insecticidal Chemistries to Mosquitoes
Published on: February 13, 2019
Potential insecticidal activity of aminonaphthoquinone Mannich bases derived from lawsone and their copper (II)
Andréia P Matos1, André L F Sarria1, Ana C Volante1
1Department of Chemistry, Natural Products Laboratory, Federal University of São Carlos (UFSCar), 13565-905, São Carlos, SP, Brazil.
Abstract:
The fall armyworm, Spodoptera frugiperda, is a polyphagous pest that causes important damage in different regions of America and mainly affects corn crops in both tropical and subtropical areas. Currently, control relies on both transgenic plants and/or chemical pesticides. In this work, we describe insecticidal activity against the fall armyworm from a series of Mannich bases (1-10), derived from 2-hydroxy-1,4-naphthoquinone (lawsone), substituted benzaldehydes, and two primary amines, and their Cu2+ complexes (11-20). The [Cu(L)2] complexes were more effective in larval mortality compared to the free Mannich bases. Among the tested compounds, complex 11 showed the highest toxicity, with 70.00% larval mortality.
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