Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

401
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
401
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

901
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
901
Acid Suppressive Drugs for Peptic Ulcer Disease: Histamine H2-Receptor Antagonists01:28

Acid Suppressive Drugs for Peptic Ulcer Disease: Histamine H2-Receptor Antagonists

752
Histamine H2 receptors, which are intricately located on the basolateral membrane of parietal cells, play a crucial role in modulating gastric acid secretion. When released from enterochromaffin-like cells, histamine engages H2 receptors, initiating the cyclic AMP (cAMP) pathway. In this pathway, adenylyl cyclase converts ATP into cAMP, elevating intracellular cAMP levels. The activation of protein kinase A follows, stimulating the proton pump. This stimulation prompts the secretion of hydrogen...
752
Pericarditis IV: Nursing Management01:25

Pericarditis IV: Nursing Management

184
Pericarditis, an inflammation of the pericardium, necessitates diligent nursing management to ensure effective patient care and recovery. The initial step in managing pericarditis is a comprehensive patient medical assessment.The patient reports chest pain aggravated by breathing, coughing, and swallowing, which worsens when lying supine. The pain often improves when sitting up and leaning forward. Additional symptoms may include fever, malaise, and, in severe cases, signs of heart failure.
184
Acid Suppressive Drugs for Peptic Ulcer Disease: Proton Pump Inhibitors01:13

Acid Suppressive Drugs for Peptic Ulcer Disease: Proton Pump Inhibitors

697
Peptic ulcers, often induced by H. pylori infections or NSAID usage, arise from disruptions in the delicate balance of gastric acid production. Peptic ulcers stem from heightened gastric acid levels due to H. pylori infections or NSAID use. The protective mucus layer diminishes in the presence of these factors, allowing gastric acid to erode the stomach lining and form ulcers.
Gastric acid, a potent cocktail of hydrogen and chloride ions, is produced in specialized parietal cells within the...
697
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

480
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
480

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multivariate assessment of morphological diversity in Moringa oleifera Lam. across agro-climatic zones of Rajasthan.

BMC ecology and evolution·2026
Same author

Venopulmonary Extracorporeal Membrane Oxygenation: Overview, Applications, and Current Evidence.

Cardiology in review·2026
Same author

PVC Variability and Impact on Meeting Expert Consensus Cutoffs of ≥ 10 000 PVCs/Day and ≥ 15% PVCs.

Journal of cardiovascular electrophysiology·2026
Same author

Regulatory dynamics of molecular determinants in divergent rice varieties under the influence of nano-structured Zinc: an integrative study of OsbZIP genes and their targeting miRNAs.

BMC plant biology·2026
Same author

Feasibility of the caudal tunneling with lateral colonic attachment preservation procedure in laparoscopic right hemicolectomy for ileocecal tuberculosis: a prospective cohort study.

Annals of coloproctology·2026
Same author

Extracorporeal membrane oxygenation in cardiogenic shock: evidence, limitations, and patient selection in the contemporary era.

Postgraduate medicine·2026

Related Experiment Video

Updated: Dec 4, 2025

Author Spotlight: Exploring Corneal Innate Immunity and Delayed Wound Healing in Diabetic Patients
03:57

Author Spotlight: Exploring Corneal Innate Immunity and Delayed Wound Healing in Diabetic Patients

Published on: January 10, 2025

16.9K

Naproxen-induced thrombocytopenia.

Nitasa Sahu1, Justin Roy1, Rama Vunnam1

  • 1Milton S. Hershey Penn State Medical Center, Hershey, Pennsylvania.

Proceedings (Baylor University. Medical Center)
|October 26, 2020
PubMed
Summary
This summary is machine-generated.

Drug-induced thrombocytopenia can cause serious bleeding, like hemarthrosis. Naproxen was identified as the cause in a patient presenting with acute thrombocytopenia and joint bleeding.

Keywords:
Drug-induced thrombocytopeniahematologyinternal medicine

More Related Videos

Real-Time, High-Throughput Microscopic Quantification of Human Neutrophil Extracellular Trap Release and Assessing the Pharmacology of Antagonists
11:32

Real-Time, High-Throughput Microscopic Quantification of Human Neutrophil Extracellular Trap Release and Assessing the Pharmacology of Antagonists

Published on: October 18, 2024

952
Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity
09:32

Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity

Published on: October 17, 2025

220

Related Experiment Videos

Last Updated: Dec 4, 2025

Author Spotlight: Exploring Corneal Innate Immunity and Delayed Wound Healing in Diabetic Patients
03:57

Author Spotlight: Exploring Corneal Innate Immunity and Delayed Wound Healing in Diabetic Patients

Published on: January 10, 2025

16.9K
Real-Time, High-Throughput Microscopic Quantification of Human Neutrophil Extracellular Trap Release and Assessing the Pharmacology of Antagonists
11:32

Real-Time, High-Throughput Microscopic Quantification of Human Neutrophil Extracellular Trap Release and Assessing the Pharmacology of Antagonists

Published on: October 18, 2024

952
Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity
09:32

Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity

Published on: October 17, 2025

220

Area of Science:

  • Hematology
  • Pharmacology
  • Internal Medicine

Background:

  • Thrombocytopenia presents with diverse etiologies requiring thorough clinical evaluation and diagnostic testing.
  • Drug-induced thrombocytopenia (DITP) is a significant cause of low platelet counts, often overlooked due to voluntary reporting and diagnostic challenges.

Observation:

  • A patient experienced an acute drop in platelet levels and subsequent hemarthrosis.
  • The patient's condition was linked to recent exposure to naproxen, a common nonsteroidal anti-inflammatory drug.

Findings:

  • This case highlights naproxen as a potential trigger for drug-induced thrombocytopenia.
  • Proving DITP can be difficult, as drug metabolites, not the parent drug, are often implicated, complicating antibody testing.

Implications:

  • Clinicians must maintain a high index of suspicion for DITP in patients with acute thrombocytopenia after drug exposure.
  • Recognizing naproxen-induced thrombocytopenia is crucial for timely diagnosis and management to prevent complications such as hemarthrosis.