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Updated: Dec 4, 2025
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Tuning the Acidity of Pt/ CNTs Catalysts for Hydrodeoxygenation of Diphenyl Ether
Published on: August 17, 2019
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Optimization of a Decatungstate-Catalyzed C(sp3)-H Alkylation Using a Continuous Oscillatory Millistructured
Zhenghui Wen1, Apoorva Maheshwari1, Carlo Sambiagio1
1Department of Chemical Engineering and Chemistry, Micro Flow Chemistry & Synthetic Methodology, Eindhoven University of Technology, Den Dolech 2, 5612 AZ Eindhoven, The Netherlands.
Organic Process Research & Development
|October 26, 2020
Summary
Tetrabutylammonium decatungstate (TBADT) is a versatile photocatalyst for C-H bond cleavage. A new flow photoreactor significantly boosts productivity for decatungstate-catalyzed C(sp3)-H alkylation.
Area of Science:
- Photocatalysis
- Organic Synthesis
- Flow Chemistry
Background:
- Tetrabutylammonium decatungstate (TBADT) is an effective photocatalyst for hydrogen atom transfer (HAT) reactions.
- TBADT facilitates the cleavage of activated and unactivated aliphatic C-H bonds.
Purpose of the Study:
- To investigate a decatungstate-catalyzed C(sp3)-H alkylation protocol using a novel oscillatory millistructured continuous-flow photoreactor.
- To evaluate the reactor's performance based on various chemical and process parameters.
Main Methods:
- Utilized an oscillatory millistructured continuous-flow photoreactor.
- Investigated decatungstate-catalyzed C(sp3)-H alkylation.
- Optimized parameters including residence time, light intensity, catalyst loading, and substrate/reagent concentration.
Main Results:
- Achieved significantly higher productivity compared to batch and previous flow protocols.
- Demonstrated a throughput of up to 36.7 mmol/h.
- Reduced residence time to only 7.5 minutes.
Conclusions:
- The novel flow photoreactor enhances the efficiency of TBADT-catalyzed C-H alkylation.
- Optimized conditions in flow chemistry lead to superior productivity and reduced reaction times.
- This advancement offers a more efficient method for C-H bond functionalization.
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