Effect of Vitamin D Injection in Recurrent Benign Paroxysmal Positional Vertigo with Vitamin D Deficiency

Area of Science:

• Neurology
• Endocrinology
• Otolaryngology

Background:

• Recurrent benign paroxysmal positional vertigo (BPPV) has been linked to vitamin D deficiency.
• Some studies suggest vitamin D treatment may reduce BPPV recurrence.

Purpose of the Study:

• To investigate the effect of vitamin D3 injections on BPPV recurrence in patients with low vitamin D levels (≤10 ng/mL).

Main Methods:

• A case-control study involving 99 patients with idiopathic BPPV and vitamin D deficiency.
• 25 patients received 3-4 injections of 200,000 IU vitamin D3 in the first year (case group).
• 50 patients were frequency-matched as controls, with follow-up for 24 months.

Main Results:

• No statistically significant differences in BPPV relapse rates were observed between the vitamin D3 injection group and the control group.
• Relapse rates were compared at 0-6 months, 7-12 months, 13-24 months, and over the entire 24-month study period.
• Statistical analysis (Kruskal-Wallis test) showed no significant differences (p > 0.05) in any period.

Conclusions:

• Vitamin D3 injections showed no significant effect on reducing the recurrence of BPPV in vitamin D-deficient patients.
• The findings were consistent across different follow-up periods and when controlling for age, gender, and BPPV type.