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Updated: Dec 4, 2025

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Clinical Relevance of Pharmacogenetics in Serotonin Syndrome
Dehuti Pandya1, My Tran2, Monica Verduzco-Gutierrez3
1Department of Pharmacy, TIRR Memorial Hermann Hospital, 1333 Moursund St., Houston TX 77030, USA.
Abstract:
Serotonin syndrome is a predictable life-threatening condition that is caused by serotonergic stimulation of the central and peripheral nervous systems. A patient's genetic profile can amplify exposure risk as many serotonergic drugs are metabolized by CYP450 enzymes, and these enzymes may be altered in functionality. We report a case of an elderly man who presented with serotonin syndrome after a dose change in valproic acid 5 weeks prior. His medication list consisted of low-dose serotonergic agents, which is unusual as most cases of serotonin syndrome involve higher doses. A review of his pharmacogenetic profile is presented to retrospectively evaluate the additive risk for serotonin syndrome and implications on resuming serotonergic agents.
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