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Detection of a Meckel's diverticulum on PSMA PET/CT: A case report

Mitchell M Huang1, Hiten D Patel1, Andres Matoso1,2

  • 1The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Urology Case Reports
|October 26, 2020
PubMed

Insights

A common gastrointestinal issue, Meckel's diverticulum, was unexpectedly found during prostate cancer staging using PSMA PET/CT scans. This report explores reasons for its high radiotracer uptake and clinical significance.

Area of Science:

  • Gastroenterology
  • Nuclear Medicine
  • Oncology

Background:

  • Meckel's diverticulum is the most frequent congenital anomaly of the gastrointestinal tract.
  • Prostate-specific membrane antigen (PSMA) PET/CT is a key imaging modality for prostate cancer staging.
  • Incidental findings during imaging can reveal unexpected pathologies.

Observation:

  • A case of Meckel's diverticulum incidentally identified during PSMA PET/CT for prostate cancer staging is presented.
  • The Meckel's diverticulum exhibited significant uptake of the PSMA-targeted radiotracer.

Findings:

  • The incidental finding of Meckel's diverticulum on PSMA PET/CT highlights potential tracer accumulation in non-prostate related tissues.
  • Hypotheses regarding the mechanism of PSMA radiotracer uptake in the diverticulum are discussed.

Implications:

  • Understanding incidental findings on PSMA PET/CT is crucial for accurate cancer staging and patient management.
  • This observation may prompt further investigation into PSMA expression in gastrointestinal tissues.
  • Clinicians should be aware of potential false positives or incidental findings in unrelated organs during PSMA PET/CT scans.
Keywords:
Functional imagingMeckel's diverticulumPET/CTPSMAProstate cancer

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