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Ceria Nanoparticles Decrease UVA-Induced Fibroblast Death Through Cell Redox Regulation Leading to Cell Survival,

Fabianne Martins Ribeiro¹, Mariana Maciel de Oliveira², Sushant Singh³

¹Programa de Pós-Graduação em Ciências Biológicas, Universidade Estadual de Maringá, Maringá, Brazil.

Frontiers in Bioengineering and Biotechnology

|October 26, 2020

Summary

Low-dose nanoceria protect skin cells from ultraviolet A (UVA) damage by reducing oxidative stress and promoting cell survival, migration, and proliferation. This suggests nanoceria as a potential therapeutic agent against UVA-induced photodamage and aging.

Keywords:

antioxidant nanoceria photoaging ultraviolet radiation wound healing

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Area of Science:

Dermatology
Nanotechnology
Biochemistry

Background:

Ultraviolet radiation (UVA) causes premature skin aging and cancer via reactive oxygen species (ROS) overproduction.
Nanomaterials are being explored for photoaging prevention strategies.
Cerium oxide nanoparticles (nanoceria) possess ROS-scavenging enzyme-like activity.

Purpose of the Study:

To investigate the protective effects of low-dose nanoceria against UVA-induced oxidative stress in fibroblasts.
To evaluate nanoceria's impact on cell survival, migration, proliferation, and aging markers.

Main Methods:

Fibroblast cells (L929) were pretreated with 100 nM nanoceria before UVA exposure.
Assessed cell viability, ROS production, antioxidant enzyme activity (SOD, GSH), apoptosis markers (Caspase 3/7), mitochondrial membrane potential, cell migration (wound healing assay), proliferation, and ERK 1/2 phosphorylation.

Main Results:

Nanoceria pretreatment showed no cytotoxicity and protected cells from UVA-induced death.
Nanoceria inhibited ROS production, restored SOD activity and GSH levels, and decreased Caspase 3/7 levels and mitochondrial potential loss.
Nanoceria enhanced cell survival, migration, and proliferation, reduced cellular aging, and decreased ERK 1/2 phosphorylation.

Conclusions:

Low-dose nanoceria effectively combat UVA-induced oxidative damage in skin cells.
Nanoceria act as a potential adjunct to endogenous antioxidants, enhancing redox potential to protect against photodamage.
Nanoceria modulate cell survival, migration, and proliferation, offering a promising strategy for photoaging prevention.