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Progress in organ 3D bioprinting.

Fan Liu1,2, Chen Liu1, Qiuhong Chen1

  • 1Department of Tissue Engineering, Center of 3D Printing and Organ Manufacturing, School of Fundamental Sciences, China Medical University (CMU), Shenyang, China.

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|October 26, 2020
PubMed
Summary
This summary is machine-generated.

3D bioprinting shows promise for creating large organs like bone and skin, but faces challenges, especially in vascular network development. Further research is needed to advance this technology for medical applications.

Keywords:
3D bioprintingbonecartilageheartliverorganskin

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Area of Science:

  • Biotechnology
  • Regenerative Medicine
  • 3D Printing Technology

Background:

  • Three-dimensional (3D) printing is a transformative technology with significant implications across scientific, technological, and commercial sectors.
  • Human organ 3D bioprinting has emerged as a notable concept, attracting substantial scientific interest and investment.
  • Despite advancements, 3D bioprinting of large organs remains complex, requiring extensive scientific and technical expertise.

Purpose of the Study:

  • To provide an overview of the current achievements in 3D bioprinting technologies for large organ manufacturing.
  • To highlight the challenges and complexities associated with large organ bioprinting, particularly vascularization.

Main Methods:

  • Review of existing literature and research on 3D bioprinting applications in organ fabrication.
  • Analysis of key advancements in creating complex biological structures using 3D printing.

Main Results:

  • Significant progress has been made in 3D bioprinting various large organs, including bone, liver, heart, cartilage, and skin.
  • A major hurdle in large organ bioprinting is the successful creation of implantable, branched vascular networks within a 3D construct.
  • The field of organ 3D bioprinting is still in its early stages, with substantial work remaining.

Conclusions:

  • 3D bioprinting holds immense potential for organ regeneration and replacement.
  • Overcoming challenges in vascularization and scalability is crucial for clinical translation.
  • Continued research and development are essential to realize the full capabilities of 3D bioprinting for complex organ manufacturing.