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[PHYSIOLOGICAL GENDER DIFFERENCES AND THEIR EFFECT ON COVID-19 CAUSED MORBIDITY]

Evgenia Muginshtein-Simkovitch1, Itay Ketko1, Ariel Furer1,2

  • 1Medical Corps, Israel Defense Forces.

Harefuah
|October 26, 2020
PubMed

Insights

This review explores how biological sex differences may impact COVID-19 outcomes. Understanding these variations is crucial for developing tailored prevention and treatment strategies for men and women.

Area of Science:

  • Medical Science
  • Epidemiology
  • Infectious Diseases

Background:

  • The COVID-19 pandemic caused significant global health and economic challenges.
  • Biological differences between sexes may affect disease response and treatment efficacy.
  • Existing research has not fully explored these sex-based disparities in COVID-19.

Purpose of the Study:

  • To review and analyze the existing literature on sex differences in COVID-19.
  • To investigate how anatomical, physiological, and occupational factors influence COVID-19 infection, pathogenesis, and prognosis in women versus men.

Main Methods:

  • Literature review and synthesis of current research findings.
  • Analysis of studies investigating sex-specific COVID-19 epidemiology and clinical outcomes.
  • Examination of biological and social factors contributing to sex-based differences.

Main Results:

  • Preliminary evidence suggests potential sex-based variations in COVID-19 susceptibility and severity.
  • Differences in immune responses, comorbidities, and hormonal factors may play a role.
  • Occupational and social factors also contribute to differential exposure and outcomes.

Conclusions:

  • Sex is a critical factor influencing COVID-19 infection, pathogenesis, and prognosis.
  • Further research is needed to elucidate specific mechanisms and inform sex-specific clinical management.
  • Recognizing and addressing sex differences can improve public health strategies and patient care.
Abstract

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