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Related Experiment Video

Updated: Dec 3, 2025

Enrichment of Bruch's Membrane from Human Donor Eyes
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Morphological differences between two types of Bruch's membrane defects in pathologic myopia.

Jiamin Xie1,2,3,4, Qiuying Chen1,2,3,4, Guangyi Hu1,2,3,4

  • 1Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, China.

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
|October 26, 2020
PubMed
Summary
This summary is machine-generated.

Choroidal and scleral differences distinguish patchy atrophy (PA) and CNV-related macular atrophy (CNV-MA). Swept-source OCT is crucial for classifying pathologic myopia based on these Bruch

Keywords:
CNV-related macular atrophyDome-shaped maculaPatchy atrophyScleral perforating vesselsScleral thicknessSwept-source optical coherence tomography

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Pathology

Background:

  • Bruch's membrane (BM) defects, including patchy atrophy (PA) and CNV-related macular atrophy (CNV-MA), are key features in pathologic myopia.
  • Understanding the distinct morphological characteristics of these defects is essential for accurate diagnosis and management.

Purpose of the Study:

  • To investigate and compare the morphological differences between PA and CNV-MA.
  • To explore the relationship between these defects and scleral and choroidal characteristics.

Main Methods:

  • Utilized swept-source optical coherence tomography (SS-OCT) to assess scleral thickness (ST), choroidal thickness (CT), and scleral morphology.
  • Employed fundus photography to measure the size of PA and CNV-MA lesions.
  • Included 167 eyes with either PA or CNV-MA, with some eyes exhibiting dome-shaped macula (DSM).

Main Results:

  • CNV-MA eyes without DSM had significantly thicker subfoveal ST and a higher rate of scleral perforating vessels compared to PA eyes without DSM.
  • Lesion size correlated with CT in eyes without DSM, but with bulge height in eyes with DSM.
  • Dome-shaped macula (DSM) was present in a notable percentage of both PA and CNV-MA cases.

Conclusions:

  • CNV-MA eyes exhibit thicker sclera than PA eyes, suggesting they are distinct entities.
  • Different mechanical forces may influence lesion enlargement in BM defects, potentially related to the presence of DSM.
  • SS-OCT, by evaluating scleral and choroidal morphology, is vital for precise classification of pathologic myopia.