The GALNTL6 Gene rs558129 Polymorphism Is Associated With Power Performance

Area of Science:

• Sports Genomics
• Human Genetics
• Exercise Physiology

Background:

• Previous research indicated the GALNTL6 gene rs558129 polymorphism might influence endurance performance.
• The association of this polymorphism with power performance remained unexplored.
• Other genetic variants like ACTN3, ACE, and PPARA have been linked to both endurance and power phenotypes.

Purpose of the Study:

• To investigate the association between the GALNTL6 gene rs558129 polymorphism and power performance.
• To compare the allelic frequencies of GALNTL6 rs558129 between power athletes, endurance athletes, and controls.

Main Methods:

• Wingate anaerobic test (WAnT) was performed on 85 Caucasian physically active men in Spain.
• Allelic frequencies of GALNTL6 rs558129 were compared between 173 Russian power athletes, 169 endurance athletes, and 201 controls.
• Statistical analyses included comparisons of power output and odds ratios for allele distribution.

Main Results:

• Physically active men with the GALNTL6 rs558129 T allele exhibited 5.03-6.97% higher power values compared to the CC genotype.
• The T allele was significantly over-represented in power athletes (37.0%) versus endurance athletes (29.3%) and controls (28.6%).
• Strength athletes showed the highest frequency of the T allele (43.9%) compared to endurance athletes and controls.

Conclusions:

• The GALNTL6 rs558129 T allele appears to be favorable for anaerobic performance and strength athletes.
• A potential functional role for GALNTL6 rs558129 involving gut microbiome and short-chain fatty acid regulation is proposed.
• Further research is necessary to elucidate the underlying mechanisms connecting this polymorphism to athletic performance.