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Glaucoma and Antioxidants: Review and Update
Jose Javier Garcia-Medina1,2,3,4, Elena Rubio-Velazquez1, Maria Dolores Lopez-Bernal1
1Department of Ophthalmology, General University Hospital Morales Meseguer, 30008 Murcia, Spain.
Antioxidants (Basel, Switzerland)
|October 27, 2020
Summary
Antioxidant supplementation shows promise for treating glaucoma, a neurodegenerative eye disease. Further research is needed to confirm its effectiveness in protecting retinal ganglion cells from oxidative stress.
Area of Science:
- Ophthalmology
- Neuroscience
- Cell Biology
Background:
- Glaucoma is a neurodegenerative condition affecting retinal ganglion cells.
- Oxidative stress is implicated in the pathogenesis of glaucoma and cell death.
- Antioxidant substances theoretically offer a protective mechanism against oxidative damage.
Purpose of the Study:
- To review existing literature on antioxidant supplementation in glaucoma.
- To provide an updated overview of research findings on this topic.
- To assess the potential of antioxidants as a therapeutic strategy for glaucoma.
Main Methods:
- Systematic review of published studies.
- Inclusion of research from animal models of glaucoma.
- Inclusion of data from human clinical trials.
Main Results:
- Studies reviewed present variable results regarding antioxidant effects.
- Evidence suggests a potential benefit of antioxidant supplementation.
- Further investigation is warranted to clarify efficacy and optimal use.
Conclusions:
- Antioxidant supplementation may represent a promising therapeutic avenue for glaucoma.
- Continued research is essential to validate these findings and establish clinical guidelines.
- Understanding the role of oxidative stress in glaucoma supports exploring antioxidant interventions.
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