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Updated: Dec 3, 2025

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
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Published on: March 12, 2016

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Glaucoma and Antioxidants: Review and Update

Jose Javier Garcia-Medina1,2,3,4, Elena Rubio-Velazquez1, Maria Dolores Lopez-Bernal1

  • 1Department of Ophthalmology, General University Hospital Morales Meseguer, 30008 Murcia, Spain.

Antioxidants (Basel, Switzerland)
|October 27, 2020
PubMed

Insights

Antioxidant supplementation shows promise for treating glaucoma, a neurodegenerative eye disease. Further research is needed to confirm its effectiveness in protecting retinal ganglion cells from oxidative stress.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Cell Biology

Background:

  • Glaucoma is a neurodegenerative condition affecting retinal ganglion cells.
  • Oxidative stress is implicated in the pathogenesis of glaucoma and cell death.
  • Antioxidant substances theoretically offer a protective mechanism against oxidative damage.

Purpose of the Study:

  • To review existing literature on antioxidant supplementation in glaucoma.
  • To provide an updated overview of research findings on this topic.
  • To assess the potential of antioxidants as a therapeutic strategy for glaucoma.

Main Methods:

  • Systematic review of published studies.
  • Inclusion of research from animal models of glaucoma.
  • Inclusion of data from human clinical trials.

Main Results:

  • Studies reviewed present variable results regarding antioxidant effects.
  • Evidence suggests a potential benefit of antioxidant supplementation.
  • Further investigation is warranted to clarify efficacy and optimal use.

Conclusions:

  • Antioxidant supplementation may represent a promising therapeutic avenue for glaucoma.
  • Continued research is essential to validate these findings and establish clinical guidelines.
  • Understanding the role of oxidative stress in glaucoma supports exploring antioxidant interventions.
Keywords:
antioxidantglaucomaoxidative stress

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