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DLEU2: A Meaningful Long Noncoding RNA in Oncogenesis.
Wen Xu1, Bei Wang1, Yuxuan Cai1
1College of Medical Science, China Three Gorges University, Yichang 443002, China.
Current Pharmaceutical Design
|October 27, 2020
Summary
The long non-coding RNA DLEU2 is implicated in numerous cancers, acting as both an oncogene and tumor suppressor. Its abnormal expression affects cancer cell proliferation, migration, and apoptosis, suggesting its potential as a therapeutic target.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Long non-coding RNAs (lncRNAs) play crucial roles in cancer, influencing epigenetic regulation, DNA damage, and signaling pathways.
- LncRNAs can function as oncogenes or tumor suppressors through transcriptional regulation.
- The lncRNA DLEU2 is implicated in various cancers, including leukemia, and its molecular mechanisms in tumors are under investigation.
Purpose of the Study:
- To review and analyze the biological functions and mechanisms of DLEU2 in tumors.
- To systematically retrieve and collect related research on DLEU2 from PubMed.
Main Methods:
- Literature review and analysis of current studies on DLEU2 in tumors.
- Systematic retrieval of research articles through PubMed.
Main Results:
- DLEU2 is abnormally expressed in diverse malignancies such as leukemia, lung cancer, and breast cancer.
- DLEU2 influences cancer cell proliferation, migration, invasion, and apoptosis.
- DLEU2 has been identified in chronic lymphocytic leukemia and numerous other cancers.
Conclusions:
- DLEU2's diverse roles in cancer suggest its potential as a diagnostic biomarker.
- DLEU2 may serve as a promising therapeutic target for various malignant tumors.
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