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Visualizing a protonated RNA state that modulates microRNA-21 maturation

Jared T Baisden1, Joshua A Boyer1, Bo Zhao1,2

  • 1Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Nature Chemical Biology
|October 27, 2020
PubMed
Summary

MicroRNA maturation is regulated by pH-dependent structural dynamics. The precursor of microRNA-21 uses an alternative conformation to enhance Dicer processing, revealing a new layer of microRNA biogenesis control.

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