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Resting Brain Fluctuations Are Intrinsically Coupled to Visual Response Dynamics.

Michaël E Belloy1,2, Jacob Billings3, Anzar Abbas3

  • 1Department of Pharmaceutical, Veterinary and Biomedical Sciences, University of Antwerp, 2610 Antwerp, Belgium.

Cerebral Cortex (New York, N.Y. : 1991)
|October 27, 2020
PubMed
Summary

Quasiperiodic patterns (QPPs) in mouse brains significantly influence sensory processing by reflecting brain state fluctuations. These dynamics, involving default mode and task-positive networks, impact how the brain responds to external stimuli.

Keywords:
brain statedefault mode (DMN) and task-positive network (TPN)functional MRIneuromodulationvisual stimulation

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Area of Science:

  • Neuroscience
  • Brain Dynamics
  • Sensory Processing

Background:

  • Understanding the interplay between intrinsic brain activity and external stimuli is crucial.
  • Resting-state brain dynamics may pre-condition neural responses to sensory input.

Purpose of the Study:

  • To investigate how intrinsic brain dynamics, specifically quasiperiodic patterns (QPPs), interact with visual stimulus processing in mice.
  • To determine if QPPs reflect brain states that modulate sensory response magnitude.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was used to track whole-brain spatiotemporal activity patterns in anesthetized mice.
  • Analysis focused on resting conditions and visual stimulation trials, examining QPPs and network interactions.

Main Results:

  • Quasiperiodic patterns (QPPs) were identified as the dominant component of resting brain dynamics in mice.
  • QPPs aligned anticorrelations between default mode (DMN) and task-positive (TPN) networks, global fluctuations, and reticular formation activity.
  • The phase of QPPs before stimulation predicted subsequent visual response magnitude, indicating a link to brain state fluctuations.

Conclusions:

  • Intrinsic brain dynamics, characterized by QPPs, significantly influence sensory processing by reflecting brain state fluctuations.
  • These dynamics, potentially orchestrated by neuromodulation, affect how the brain processes external sensory information.
  • Findings offer new insights into neural mechanisms shaping brain states and modulating sensory input.