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Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy
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Measuring Functional Status in Huntington's Disease.

Jessie S Gibson1, Sheila H Ridner2, Mary S Dietrich2,3

  • 1School of Nursing, University of Virginia, Charlottesville, Virginia, USA.

Movement Disorders : Official Journal of the Movement Disorder Society
|October 27, 2020
PubMed
Summary
This summary is machine-generated.

In Huntington's disease (HD), neuropsychiatric, cognitive, and motor symptoms significantly impair function, especially when measured by the Adult Functional Adaptive Behavior (AFAB) scale. The Total Functional Capacity (TFC) scale is less sensitive to these changes.

Keywords:
Huntington's disease; patient outcome assessment; neuropsychiatry; activities of daily living

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Area of Science:

  • Neuroscience
  • Clinical Neurology
  • Movement Disorders

Background:

  • Huntington's disease (HD) presents significant neuropsychiatric and cognitive challenges.
  • Existing functional status measures like the Total Functional Capacity (TFC) scale may not fully capture the impact of these symptoms.

Purpose of the Study:

  • To evaluate the impact of motor, cognitive, and neuropsychiatric symptoms on functional status in individuals with HD.
  • To compare the efficacy of the TFC scale versus the Adult Functional Adaptive Behavior (AFAB) scale in assessing functional status in HD.

Main Methods:

  • Utilized multiple regression analyses to examine the relationship between symptom domains and functional status.
  • Assessed functional status using both the TFC and AFAB scales.

Main Results:

  • A greater burden of neuropsychiatric, cognitive, and motor symptoms correlated with increased functional impairment on the AFAB scale.
  • Only motor symptoms showed a significant association with TFC scores.
  • The three symptom domains collectively explained more variance in AFAB scores than in TFC scores.

Conclusions:

  • The TFC scale may have limited utility for measuring functional status in HD, particularly in early stages.
  • The AFAB scale offers a more comprehensive assessment of functional status in HD research.