Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

5.0K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.0K
Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

3.5K
A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
3.5K
Generalized Anxiety Disorder01:30

Generalized Anxiety Disorder

489
Generalized Anxiety Disorder (GAD) is a chronic condition characterized by excessive and uncontrollable worry that persists for at least six months, significantly interfering with daily functioning. Unlike situational anxiety, which arises in response to specific stressors, GAD often occurs without a clear cause. Individuals may experience disproportionate worry about work, health, or relationships. For instance, a person might continuously fear poor health despite normal medical evaluations or...
489
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

529
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
529
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

657
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
657
Chronic Pharyngitis01:23

Chronic Pharyngitis

8.7K
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
8.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Swiss Prison Study (SWIPS): Results from a registry-based study of prisoners in Switzerland from 2015 to 2020.

Swiss medical weekly·2024
Same author

[Complications of intravesical BCG therapy].

Praxis·2024
Same author

Low secondary attack rate after prolonged exposure to sputum smear positive miliary tuberculosis in a neonatal unit.

Antimicrobial resistance and infection control·2022
Same author

Enoxaparin for outpatients with COVID-19: 90-day results from the randomised, open-label, parallel-group, multinational, phase III OVID trial.

Thrombosis research·2022
Same author

Nosocomial COVID-19 Incidence and Secondary Attack Rates among Patients of Tertiary Care Center, Zurich, Switzerland.

Emerging infectious diseases·2022
Same author

Identifying Contact Risks for SARS-CoV-2 Transmission to Healthcare Workers during Outbreak on COVID-19 Ward.

Emerging infectious diseases·2022

Related Experiment Video

Updated: Dec 3, 2025

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
04:59

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors

Published on: September 27, 2019

12.8K

[CME: Chronic Generalized Pruritus without Dermatological Cause].

Liliana Petruse1, Holger Kiesel2, Silvana K Rampini1

  • 1Klinik und Poliklinik für Innere Medizin, Universitätsspital Zürich.

Praxis
|October 28, 2020
PubMed
Summary

Chronic generalized pruritus, often without skin issues, can signal serious systemic diseases. Early diagnosis through history, examination, and labs is crucial for identifying underlying conditions like malignancy.

Keywords:
Chronic pruritusChronischer PruritusHodgkin lymphomaHodgkin-LymphomMalignitätSystemerkrankungmalignancysystemic diseases

More Related Videos

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

24.8K
Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

10.0K

Related Experiment Videos

Last Updated: Dec 3, 2025

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
04:59

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors

Published on: September 27, 2019

12.8K
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

24.8K
Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

10.0K

Area of Science:

  • Internal Medicine
  • Dermatology
  • Clinical Diagnostics

Background:

  • Chronic generalized pruritus is a frequent symptom.
  • Dermatological causes must be differentiated from non-dermatological origins.
  • Non-dermatological pruritus can stem from systemic, infectious, neurological, psychogenic, or drug-related causes, often with significant morbidity.

Purpose of the Study:

  • To outline an approach for diagnosing chronic generalized pruritus in adults without apparent skin lesions.
  • To discuss differential diagnoses and a clarification strategy for non-dermatological pruritus.
  • To emphasize considering systemic diseases, including malignancy, as potential causes.

Main Methods:

  • Review of clinical presentation and diagnostic considerations for chronic generalized pruritus.
  • Emphasis on thorough patient history and physical examination.
  • Highlighting the role of selected laboratory investigations in diagnosis.

Main Results:

  • Generalized pruritus without dermatological signs may indicate underlying systemic disease.
  • Pruritus can be an early indicator of malignant hematological diseases or solid tumors.
  • A systematic diagnostic approach is essential for identifying the cause.

Conclusions:

  • Systemic diseases should be suspected in patients with generalized pruritus and no primary skin lesions.
  • A combination of clinical evaluation and laboratory testing aids in diagnosis.
  • Identifying the underlying cause of pruritus is critical due to potential associated morbidity.