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Related Concept Videos

Bone Disorders01:29

Bone Disorders

4.9K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Bone Remodeling01:40

Bone Remodeling

39.7K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
39.7K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

4.6K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
4.6K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.6K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.6K
Menopause01:28

Menopause

3.4K
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
3.4K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

3.5K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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Related Experiment Video

Updated: Dec 3, 2025

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
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Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

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Post-menopausal Osteoporosis and Probiotics.

Sangeeta Huidrom1, Mirza Atif Beg1, Tariq Masood2

  • 1Department of Pharmacology, Shri Guru Ram Rai Institute of Medical and Health Sciences, Dehradun - 248001, Uttarakhand, India.

Current Drug Targets
|October 28, 2020
PubMed
Summary

Probiotics may offer a safe and effective alternative for treating postmenopausal osteoporosis (PMO). This review explores how gut bacteria influence bone health and summarizes probiotic benefits in PMO models and women.

Keywords:
Gut microbiotaPostmenopausal osteoporosis (PMOanimal modebone healthbone remodelingprobiotics

More Related Videos

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice
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Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

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Related Experiment Videos

Last Updated: Dec 3, 2025

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

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Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice
07:20

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

854

Area of Science:

  • Bone Biology and Metabolism
  • Microbiome Research
  • Women's Health

Background:

  • Postmenopausal osteoporosis (PMO) involves bone loss due to estrogen deficiency, increasing fracture risk.
  • Current PMO treatments have side effects, including potential tumorigenesis, necessitating safer alternatives.
  • Emerging evidence links intestinal microbiota to bone health.

Purpose of the Study:

  • To review bone remodeling processes.
  • To elucidate the role of intestinal microbiota in bone metabolism.
  • To summarize current research on probiotics for PMO.

Main Methods:

  • Literature review of bone remodeling.
  • Analysis of studies on gut microbiota and bone health.
  • Synthesis of research on probiotic interventions in PMO.

Main Results:

  • Estrogen deficiency disrupts bone remodeling, favoring resorption over formation.
  • Intestinal microbiota composition influences host bone metabolism.
  • Probiotic interventions show promise in animal models and human studies of PMO.

Conclusions:

  • Probiotics represent a potential therapeutic strategy for postmenopausal osteoporosis.
  • Modulating the gut microbiota could be a novel approach to bone health management.
  • Further research is warranted to optimize probiotic use for PMO.