Related Experiment Video

Updated: Dec 3, 2025

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

4.7K

The COVID-19 nephrology compendium: AKI, CKD, ESKD and transplantation

Sam Kant1, Steven P Menez1, Mohamed Hanouneh1,2

  • 1Department of Medicine, Johns Hopkins School of Medicine, 5601 Loch Raven Boulevard, Suite 3 North, Baltimore, MD, 21205, USA.

BMC Nephrology
|October 28, 2020
PubMed

Insights

Coronavirus disease 2019 (CoVID-19) frequently causes acute kidney injury (AKI) in severe cases, leading to worse outcomes. Management of chronic kidney disease and kidney transplant patients requires careful monitoring during the pandemic.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • The coronavirus disease 2019 (CoVID-19) pandemic has presented unprecedented global health challenges.
  • CoVID-19 impacts multiple organ systems, with acute kidney injury (AKI) being a significant complication in critically ill patients.
  • Kidney transplant recipients, often on immunosuppression, may face heightened susceptibility and mortality risks from CoVID-19.

Purpose of the Study:

  • To summarize the impact of CoVID-19 on kidney function and patients with kidney diseases.
  • To review the incidence, mechanisms, and management strategies for AKI in CoVID-19 patients.
  • To highlight considerations for chronic kidney disease and kidney transplant recipients during the pandemic.

Main Methods:

  • Review of international studies and clinical observations regarding CoVID-19 and kidney injury.
  • Elucidation of various patterns and mechanisms contributing to AKI in CoVID-19.
  • Analysis of consequences on longitudinal management of chronic kidney disease and end-stage kidney disease patients.

Main Results:

  • CoVID-19 is associated with a high incidence of AKI, particularly in critical care settings, correlating with worse patient outcomes.
  • Variable incidence rates of AKI are reported globally, but consistently poor outcomes are noted in severe cases.
  • Novel strategies for renal replacement therapy and adjustments in immunosuppression for transplant recipients have been explored.

Conclusions:

  • Acute kidney injury is a major complication of CoVID-19, necessitating vigilant monitoring and management.
  • Longitudinal care for patients with chronic kidney disease and end-stage kidney disease requires adaptation during the pandemic.
  • Recommendations include increased disease surveillance, early testing, and tailored immunosuppression adjustments for kidney transplant recipients.

Keywords:
AKICKDCoVID-19DisparityESKDTransplantation

More Related Videos

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

1.2K
TBase - an Integrated Electronic Health Record and Research Database for Kidney Transplant Recipients09:00

TBase - an Integrated Electronic Health Record and Research Database for Kidney Transplant Recipients

Published on: April 13, 2021

5.0K

Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
383
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
231
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
170
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
162
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
187
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
389