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A comparison of histamine and methacholine bronchial challenges using the DeVilbiss 646 nebulizer and the
1Academic Department of Respiratory Medicine, St Bartholomew's Hospital, West Smithfield, London.
Abstract:
We have compared bronchial challenge with both histamine and methacholine for the tidal breathing method and dosimeter method, using the DeVilbiss 646 nebulizer, in 18 patients with asthma. There was a significant difference between the PC20 FEV1 but not the PD20 FEV1 when either agonist was administered by the different techniques but not by the same method.