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Updated: Dec 3, 2025

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

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Implication of the Gut Microbiota in Metabolic Inflammation Associated with Nutritional Disorders and Obesity

Julie Rodriguez1, Marta Olivares1, Nathalie M Delzenne1

  • 1Metabolism and Nutrition Research Group, Louvain Drug Research Institute, UCLouvain, Université catholique de Louvain, Brussels, 1200, Belgium.

Molecular Nutrition & Food Research
|October 28, 2020
PubMed
Abstract

Insights

Metabolic endotoxemia, where microbial components cross the gut barrier causing inflammation, is influenced by nutrition. This review explores how gut microbiota metabolites impact gut barrier integrity and metabolic inflammation, particularly in obesity.

Area of Science:

  • Microbiology
  • Nutrition Science
  • Immunology

Background:

  • Metabolic endotoxemia involves microbial components (MAMPs) breaching the gut barrier, leading to low-grade systemic inflammation.
  • Lipopolysaccharide translocation and its role in systemic inflammation are extensively studied in obesity models.
  • Gut barrier dysfunction contributes to inflammation and metabolic/behavioral changes in various pathologies.

Purpose of the Study:

  • To review the role of nutrition in metabolic regulation.
  • To examine the gut microbiota's contribution to bioactive metabolite production.
  • To detail how nutrient-derived metabolites affect gut barrier integrity, inflammation, and metabolic complications.

Main Methods:

  • Literature review focusing on nutrition, gut microbiota, and metabolic inflammation.
  • Analysis of studies investigating gut barrier function and microbial translocation.
  • Synthesis of research on nutrient-derived metabolites and their systemic effects.

Main Results:

  • Nutritional disorders significantly impact gut microbiota composition and metabolic inflammation.
  • Gut microbiota produces diverse bioactive metabolites with regulatory functions.
  • Specific nutrient-derived metabolites influence gut barrier integrity and peripheral tissues.

Conclusions:

  • Nutrition is a key modulator of metabolic regulation via the gut microbiota.
  • Gut microbiota metabolites play a crucial role in maintaining gut barrier integrity.
  • Understanding these metabolites is vital for addressing obesity and associated metabolic complications.

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