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Pathogenesis guided therapeutic management of COVID-19: an immunological perspective

Ashutosh Kumar1,2, Pranav Prasoon1,3, Prakash S Sekhawat1,4

  • 1Etiologically Elusive Disorders Research Network (EEDRN), New Delhi, India.

International Reviews of Immunology
|October 28, 2020
PubMed

Insights

The Coronavirus disease 2019 (COVID-19) pandemic has high mortality due to non-standardized treatments. This review explores host-virus interactions, pathogenic mechanisms, and potential therapeutic strategies for COVID-19.

Area of Science:

  • Immunology
  • Virology
  • Pathology

Background:

  • The Coronavirus disease 2019 (COVID-19) pandemic presents a significant global health challenge, characterized by high mortality rates.
  • A primary driver of this mortality is the lack of standardized therapeutic interventions.
  • Emerging evidence highlights SARS-CoV-2-induced immune cell dysregulation and subsequent tissue damage as key pathological features.

Purpose of the Study:

  • To review the current understanding of host-virus interactions in COVID-19.
  • To deliberate on the plausible pathogenic mechanisms underlying COVID-19.
  • To identify and discuss suitable therapeutic approaches for managing COVID-19.

Main Methods:

  • Literature review of empirical evidence on host-virus interactions.
  • Analysis of emerging data on immune cell dysregulation and tissue injury in COVID-19.
  • Synthesis of information to propose pathogenic mechanisms and therapeutic strategies.

Main Results:

  • Accumulating evidence points to specific immune cell dysregulation as a critical factor in COVID-19 pathogenesis.
  • Tissue injury is a direct consequence of the host's immune response to SARS-CoV-2 infection.
  • While no definitive treatments exist, ongoing clinical trials show promising initial results.

Conclusions:

  • Understanding host-virus interactions is crucial for developing effective COVID-19 therapies.
  • Targeting immune dysregulation and mitigating tissue injury are key therapeutic considerations.
  • Further research into standardized treatment protocols is essential to reduce COVID-19 mortality.
Keywords:
Anti-viralsSARS-CoV-2betacoronavirusesimmunopathogenesistherapeutic strategy

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