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Updated: Dec 3, 2025

Author Spotlight: Exploring Abdominal VNS for Inflammatory Conditions
Published on: January 19, 2024
Noninvasive vagal nerve stimulation for gastroenterology pain disorders
Andres Gottfried-Blackmore1, Aida Habtezion1, Linda Nguyen1
1Division of Gastroenterology & Hepatology, Department of Medicine, Stanford University, Stanford, CA 94305, USA.
Abstract:
Abdominal pain continues to be a major challenge and unmet need in clinical practice. Normalization of bidirectional gut-brain signaling has generated much interest as a therapeutic approach to treat chronic abdominal pain. Vagal nerve stimulation (VNS) is emerging as a potential non-pharmacologic strategy for the treatment of abdominal pain. In this review paper, we will summarize the etiologies of chronic pain in gastrointestinal disorders and discuss the rational for VNS as a therapeutic approach to chronic abdominal pain, with particular emphasis in the gammaCore stimulator which allows for noninvasive VNS.
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